严重感染的血液净化治疗

Continuous blood purification for the treatment of severe infectious （sepsis）

严重感染（脓毒症）的根本机制在于全身炎症反应综合征，连续血液净化可以通过滤过、吸附等清除中、大分子量炎症介质，有助于脓毒症的治疗。临床应用和实验研究证实了连续血液净化技术可稳定严重脓毒症患者的心肺功能。连续血液滤过透析、连续血浆滤过吸附、高容量血液滤过技术通过降低血浆和组织中炎症介质水平而起治疗作用。连续血液净化技术在儿童脓毒症的救治中具有良好的应用前景。

The key mechanism of severe infection （sepsis） is systemic inflammatory reaction syndrome. Continuous blood purification （CBP） is helpful for treatment of sepsis through removing medium and large molecular weight inflammatory mediators. Clinical application and lab researches have confirmed that CBP can stabilize cardiopulmonary function in patients with severe sepsis. Continuous veno-venous hemodiafiltration, continuous plasma filtration absorption and high volume hemofiltration can play a role in lowering inflammatory mediators in plasma and tissue. CBP has revealed a good prospect in the treatment of severe sepsis in children.