血脂代谢与冠状动脉病变的相关性研究

Relationship between serum lipid level and severity of coronary artery atherosclerotic lesion

目的探讨血脂代谢与冠状动脉狭窄程度的相关性。方法共收集304例行冠状动脉造影术的患者,用冠状动脉病变支数及Gensini积分表示冠状动脉病变严重程度,分析患者血脂水平及其比值与冠状动脉病变的关系。结果多因素回归分析显示,年龄、TC/HDL-C与冠状动脉病变Gensini积分呈正相关(t=3.419,P<0.001;t=11.873,P<0.001),载脂蛋白A1(ApoA1)与冠状动脉病变Gensini积分呈负相关(t=-3.412,P=0.001);年龄、非HDL-C(N-HDL-C)、LDL-C/HDL-C、TC/HDL-C与冠状动脉病变支数呈正相关[OR=0.95,95%CI(-0.074,-0.034),P<0.001;OR=0.3,95%CI(-1.675,-0.765),P<0.001;OR=1.55,95%CI(-0.735,-0.144),P=0.004;OR=0.71,95%CI(-0.627,-0.054),P=0.02]。结论受检者的血脂水平与其冠状动脉病变程度密切相关,以N-HDL-C、LDL-C/HDL-C、TC/HDL-C和ApoA1对冠状动脉病变的预测性更强。

Objective To investigate the relationship between serum lipid level and severity of coronary artery disease. Methods A total of 304 consecutive patients who underwent coronary angiography were enrolled in this study. The number of diseased arteries and Gensini score were recorded for evaluation of the severity of coronary artery disease. Blood lipid profile was measured in all subjects. Results The ratios of LDL-C/HDL-C, TC/HDL-C and N-HDL-C/HDL- C were positively correlated with Gensini score. ApoA1 was negatively correlated with Gensini score. TC, N-HDL-C, LDL- C/HDL-C ratio, TC/HDL-C ratio and N-HDL-C/HDL-C ratio were positively correlated and HDL-C, apoAl negatively correlated with the number of diseased arteries. Conclusions Serum lipid profiles, especially N-HDL-C, LDL-C/HDL-C ratio, TC/HDL-C ratio and apoAl are closely related to the severity of coronary artery atherosclerotic lesion.