2型糖尿病患者亚临床动脉粥样硬化与高敏C反应蛋白水平的关系

Relationship between high sensitivity C-reactive protein and subclinical atherosclerosis in patients with type 2 diabetes

目的探讨2型糖尿病(T2DM)患者亚临床动脉粥样硬化(SAS)与高敏C反应蛋白(hsCRP)的关系。方法 170例新确诊T2DM患者随访2年后,56例出现SAS,用免疫比浊法测定T2DM伴与不伴SAS患者及健康对照组hsCRP水平。结果伴SAS组hsCRP水平[0.64(0.50～7.07)mg/L]高于不伴SAS组[0.53(0.14～7.44)mg/L,P>0.05],2组均高于健康对照组[0.36(0.10-9.60)mg/L,均为P<0.05];将SAS为因变量,以各危险因素为自变量作Logistic回归分析显示:hsCRP、年龄、三酰甘油进入回归方程(P<0.05)。结论 hsCRP、年龄、三酰甘油可能是T2DM患者SAS发生的独立危险因素。

Objective To investigate the relationship between plasma level of high sensitivity C-reactive protein （hsCRP） and subclinical atherosclerosis （SAS） in patients with type 2 diabetes （T2DM）. Methods One hundred and seventy new diagnosed T2DM patients and 56 healthy subjects were enrolled in this study. A written informed consent form was signed by each participant before enrollment. Fifty-six of the 170 T2DM patients were diagnosed as SAS after 2 years of follow-up. Plasma level of hsCRP was measured before enrollment and compared among T2DM patients with or without SAS and healthy control subjects. Risk factors of subclinical atherosclerosis in 170 T2DM patients were analyzed by using Logistic regression analysis. Results Plasma HsCRP level in T2DM patients with SAS was higher [ 0. 64 （0. 50-7.07 ） mg/L] than without [0. 53 （0. 14-7. 44） mg/L]. T2DM patients with or without SAS had higher plasma HsCRP level than healthy control subjects[0. 36（0. 10-9. 60） mg/L]. Logistic analysis showed that SAS was closely correlated with hsCRP, TG and age （all P 〈 0. 05 ）. Conclusions Our findings demonstrate that plasma hsCRP is an independent risk factor of SAS in patients with T2DM.