紫外光聚合法制备PVA-SbQ/透明质酸凝胶及其性能研究

Study on preparation and properties of PVA-SbQ/hyaluronic acid hydrogel via UV light polymerization

将透明质酸(HA)溶液和聚乙烯醇-苯乙烯基吡啶盐缩合物(PVA-SbQ)溶液混合后,通过紫外光聚合法制备光交联PVA-SbQ/透明质酸凝胶。用FT-IR和SEM对凝胶的结构进行了表征,红外结果表明,PVA-SbQ/透明质酸凝胶在紫外光照下发生交联反应,SEM结果表明,凝胶有多孔结构,并且随着PVA-SbQ含量的增加,孔径逐渐减小。研究了不同光照时间下凝胶的粘度、溶胀曲线,表明m(HA)∶m(PVA-SbQ)=1∶3的溶液在光照时间为450s时开始由稀凝胶转变为固态凝胶,凝胶的表观粘度和溶胀率达到最大。不同光照时间下载药凝胶的释药行为,表明凝胶可以通过控制光照时间实现对药物的控制释放。

Polyvinylacohol （PVA） bearing styrylpyridinium group （PVA-SbQ） is a new photosensitive polymer, styrylpyridinium group on side of PVA main chain can be cross-linked under UV radiation to form network. The （PVA-SbQ）/hyaluronic acid gel were made by mixing the solutions of PVA-SbQ and hyaluronic acid followed by UV light polymerization. Its structure was examined by means of FT-IR and SEM. FT-IR results show that the （PVA-ShQ）/hyaluronic acid gel was photo cross-linked under UV light, SEM results show that it has the porous structure and with the increase of the content of PVA-SbQ, aperture gradually decrease. The apparent viscosity of the （PVA-SbQ）/hyaluronic acid solution （re（HA） ： m（PVA-SbQ） = 1： 3） under different UV irradiation time and swelling curves of the gel were studied. The results show that the （PVA-SbQ）/hy aluronic acid solution began to conversion from dilute gel state to solid gel state at the irradiation time of 450s. The ratio of the drug release could be controlled by the irradiation time and pH value.