少年男子中长跑运动员10km训练跑对血清心肌损伤标志物水平的影响

Effects of 10-km Run on Serum Cardiac Markers in Junior Male Runner's Training

目的：观察常规训练中非力竭耐力运动前后少年运动员血清心肌损伤标志物水平的变化。方法：测定19名少年男子中长跑运动员在常规训练中一次非全力10 km跑前、运动后2 h、运动后4 h以及运动后24 h血清心肌肌钙蛋白T亚基（cTnT）、I亚基（cTnI）、CK-MB活性及CK-MB质量水平。结果：10 km跑可显著提高被试者血清cTnT、cTnI及CK-MB质量水平。运动后4 h内血清cTnT和cTnI可超过临床心肌损伤（60%以上被试者）甚至心肌梗死（10.5%~42.1%被试者）界值,而运动后24 h,血清cTnT及cTnI恢复至正常水平。另外,运动前后各观察点都有相当比例的被试者（15.8%~84.2%）CK-MB活性及质量超过心肌损伤界值。结论：非力竭性耐力运动可能引起少年运动员可逆性心肌微损伤,但其确切机制、临床意义及远期后果有待进一步研究。

Purpose： This study was designed to examine the appearance and clearance characteristics of serum cardiac markers in junior runners after a non-exhaustive endurance exercise.Method：19 trained male adolescents performed non-all-out 10-km run during routine training.The levels of cTnT,cTnI and CK-MB mass,and activities of CK-MB immediately before and two,four and twenty-four hours after exercise were measured.Results： At pre-exercise,cTnT and cTnI were at the normal range.However,CK-MB activity and CK-MB mass were above corresponding clinical cut-off values for myocardial injury.Post-exercise significant elevations above pre-exercise were observed for all biomarkers,except CKMB activity,two and four hours following the run.Similar changes were observed in the biomarkers positive rate in the subjects.Conclusions： Such findings suggest that non-exhaustive long-distance run during routine training might lead to reversible minor myocardial injury in junior runners.However,its clinical significance,long-term consequences and mechanism remain to be fully elucidated.