伴破骨细胞样巨细胞胰腺多形性癌术后肝转移1例并文献复习

Liver metastasis of osteoclast-like giant cell pleomorphic cancer of pancreas after operation:A case report and review of the literature

目的提高对伴破骨细胞样巨细胞胰腺多形性癌的认识,探讨诊治方法。方法回顾分析1例伴破骨细胞样巨细胞胰腺多形性癌术后肝转移患者的临床表现、病理改变及疗效,并复习相关文献,总结诊治经验。结果患者为58岁男性,临床表现为上腹部胀痛、食欲减退,体重减轻等非特异性症状,CT检查发现右肝占位,切除标本为结节状肿块,切面灰褐色,出血淤血改变。免疫表型表达CD68、CK、Vim、CK8&18,预后较好。结论伴破骨细胞样巨细胞的胰腺多形性癌是胰腺多形性癌的一种特殊亚型,手术切除后能获得长期存活。

Objective To study the diagnostic and treatment methods of osteoclast-like giant cell pleomorphic cancer of pancreas（PCOG）.Methods Clinical manifestations,pathological change and therapeutic effect of a patient with osteoclast-like giant cell PCOG were retrospectively analyzed with related literature reviewed and experiences in its diagnosis and treatment summarized.Results The patient was a 58-year-old male.His clinical manifestations were upper abdominal pain,anorexia,loss of weight and other non-specific symptoms.Abdominal CT demonstrated a right liver lobe occupying lesion,6cm in diameter.The resected specimen showed a nodular feature and its profile was taupe with hemorrhage and congestion.Immunophenotype expressed the CD68,CK,Vim and CK818.The prognosis of the patient was good.Conclusion Osteoclast-like giant cell PCOG is a specific subtype of pleomorphic cancer of pancreas.Its patients can survive a long time after surgical resection.