α-硫辛酸联合甲钴胺及前列地尔治疗糖尿病周围神经病变的疗效观察

Therapeutic effect of α-lipoic acid combined with mecobalamin and alprostadil on diabetic peripheral neuropathy

目的评价α硫辛酸联合甲钴胺及前列地尔治疗糖尿病周围神经病变(DPN)的疗效。方法将32例患者随机分为两组:治疗组予α-硫辛酸、甲钻胺及前列地尔,对照组予甲钴胺及前列地尔,治疗2周。观察两组临床疗效及神经传导速度(NCV)。结果治疗组总有效率达87.5%,明显高于对照组的50%(P<0.05);两组患者的神经病变主觉症状问卷(TSS)评分明显改善(P<0.05);治疗组NCV较对照组有显著提高(P<0.01)。结论临床使用α-硫辛酸联合甲钻胺及前列地尔治疗DPN安全有效。

Objective To evaluate the therapeutic effect of α-ipoic acid combined with mecobalamin and alprostadil on diabetic peripheral neuropathy（DPN）. Methods The 32 DPN patients receiving a 2 weeks of therapy were randomly divided into two groups： treatment group treated with α-lipoie acid combined with mecobalamin and alprostadil and control group treated with meeobalamin and alprostadil. The therapeutic effect and nerve conduction velocity（NCV）were observed. Results The total efficacious rate was higher in treatment group than in control group （87. 5% vs 50. 0%, P〈0. 05）. TSS score improvement in treatment group was superior to control group （P〈0.05）. NCV acceleration was more in treatment group than in control （P〈0. 01）. Conclusions Treatment with α-lipoic acid combined with mecobalamin and alprostadil in patients with DPN is safe and effective.