我国淋病奈瑟菌耐药趋势系统分析

Trend of antibiotic resistance in Neisseria gonorrhoeae in China:a systematic review

目的收集近期国内外发表的关于我国淋病奈瑟菌耐药监测文献,分析淋病奈瑟菌的耐药趋势。方法检索中国期刊全文数据库、PubMed、Cochrane数据库,筛选合格文献进行系统评价。结果在1996~2007年,最终有6篇文献入选。我国部分地区NG耐药率对青霉素（57.2%~96.3%）、环丙沙星（17.6%~99.5%）均较高;头孢曲松虽然未检测到耐药株,但中敏率高（10.8~61.0%）;壮观霉素敏感率、中敏率和耐药率分别在97.8%~100%、0~2.2%、0~1.0%之间。结论在我国,青霉素、环丙沙星已不适合用于治疗淋病。头孢曲松、壮观霉素是推荐治疗淋病的一线药物,但头孢曲松中敏率偏高,必须引起高度关注。

Objective To collect all recent references concerning surveillance of antibiotic resistance in Neisseria gonorrhoeae and analyze its tendency.Methods Database were searched by CNKI,PubMed and Cochrane.Eligible references were screened for systematic review.Results Six references were included.From 1996 to 2007,there was a high rate of resistance to penicillin and ciprofloxacin in Neisseria gonorrhoeae in certain regions of China.Although ceftriaxone resistant strain was not detected,the reduced susceptible rate was high.The rate of spectinomycin susceptible,reduced susceptible and resistant Neisseria gonorrhoeae were 97.8~100%,0~2.2%,0~1.0% respectively Conclusion In china,penicillin or ciprofloxacin should not be used in treatment of gonorrhoeae while ceftriaxone and spectinomycin can be recommended as first-line medicine.However,particular attention should be paid on account of the reduced susceptible rate of ceftriaxone to Neisseria gonorrhoeae.Moreover,the standard of surveillance of antibiotic resistance in Neisseria gonorrhoeae in China should be improved in order to guide its use in clinic more effectively.