三种肿瘤标志物联合检测在原发性肝细胞癌中的应用价值

Value of combined detection of α-L-fucosidase,sialie acid and alpha-fetoprotein for diagnosis of hepatocellular carcinoma

目的探讨联合检测患者血清中的甲胎蛋白(AFP)、α-L-岩藻糖苷酶(AFU)以及唾液酸(SA)对原发性肝细胞癌(PHC)诊断的应用价值。方法采用化学发光酶免疫法、速率法和分光光度法,分别检测原发性肝细胞癌患者、肝硬化和健康对照者的AFP、AFU和SA等三种肿瘤标志物的血清含量,并进行统计学分析。结果 AFP、AFU、SA三者联合检测、可以将诊断率提高到97.87%。结论三种肿瘤标志物AFP、α-L-AFU、SA多指标联合检测可显著提高原发性肝细胞癌(PHC)诊断阳性率,适宜于临床实验室推广应用。

Aim To detect the serum concentrations of Alpha-fetoprotein（AFP）,α-L-fucosidase（AFU）and sialic acid（SA）for diagnosis of hepatocellular carcinoma.Methods The levels of AFP,AFU and SA in 47 confirmed primary hepatocellular carninoma cases,45 cirrhosis cases and 42 healthy controls were determined with chemiluminescent enzyme immunoassay.Results The diagnostic rate could enhanced by 97.87% through combined detection of the levels of AFP,AFU and SA.Conclusion The positive rate of diagnosis of primary hepatocellular carcinoma can obviously enhanced by joint detection of AFP,AFU and SA,and it is suitable for clinical application.