夫精宫腔内授精自然周期与促排卵周期的妊娠情况

The pregnancy conditions of natural cycles and ovulation induction cycles of intrauterine insemination with husband sperm

目的:比较夫精宫腔内授精(IUI)在自然周期与促排卵周期中的妊娠情况。方法:对施行宫腔内授精的394个自然排卵周期和372个促排卵周期(分为氯米芬组和尿促性组)的妊娠情况进行回顾性分析,比较其临床妊娠率、流产率和活产率。结果:各组年龄、不孕年限差异无统计学意义(P>0.05)。自然排卵组临床妊娠率为12.44%,流产率为16.33%,活产率为10.15%;氯米芬组(CC)临床妊娠率为11.03%,流产率为22.58%,活产率为7.83%;尿促性素周期组(HMG/CC+HMG)临床妊娠率为20.88%,流产率为10.53%,活产率为18.68%。尿促性素周期组临床妊娠率、活产率明显高于自然周期组及氯米芬周期组,差异有统计学意义(P<0.05)。结论:HMG促排卵可提高IUI的临床妊娠率和活产率,虽不能明显降低流产率,但有使IUI流产率下降的趋势,可酌情在IUI中适当使用HMG促排卵以提高临床妊娠率和活产率。

Objective：To compare the pregnancy conditions of natural cycles and ovulation induction cycles of intrauterine insemination with husband sperm. Methods：The pregnancy conditions of 394 natural cycles and 372 ovulation induction cycles（divided into clomiphene group and urinary chorionic gonadotropin group） of the patients receiving intrauterine insemination with husband sperm were analyzed retrospectively,their clinical pregnancy rates,abortion rates and live birth rates were compared. Results：There was no significant difference in maternal age and infertile time among different groups（P〉0.05）.In natural ovulation group,the clinical pregnancy rate was 12.44%,the abortion rate was 16.33%,the live birth rate was 10.15%;in clomiphene group,the clinical pregnancy rate was 11.03%,the abortion rate was 22.58%,the live birth rate was 7.83%;in urinary chorionic gonadotropin group,the clinical pregnancy rate was 20.88%,the abortion rate was 10.53%,the live birth rate was 18.68%.The clinical pregnancy rate and live birth rate in urinary chorionic gonadotropin group were significantly higher than those in natural ovulation group and clomiphene group（P〈0.05）. Conclusion：HMG used in ovulation induction can increase the clinical pregnancy rate and live birth rate of intrauterine insemination with husband sperm,although it doesn’t reduce abortion rate,abortion rate shows a decreasing trend,appropriate use of HMG in ovulation induction can increase the clinical pregnancy rate and live birth rate