ASC-US患者HPV-DNA分型检测的临床意义

Clinical significance of HPV-DNA genotype detection in patients with ASC-US

目的:探讨ASC-US患者HPV-DNA分型检测的临床意义。方法:对2008年1月～2010年1月在桂林医学院附属医院妇产科同时行宫颈细胞学筛查以及HPV-DNA分型检测其中宫颈细胞学结果判读为ASC-US的138例患者的相关资料进行分析。结果:138例ASC-US患者中HPV-DNA分型检测高危亚型阳性者61例,占44.20%,其中HPV-DNA16或(和)58亚型阳性者46例,占总数的33.33%,占高危阳性的75.41%。HPV-DNA高危亚型阳性对CINⅡ及以上病变检出的敏感度为91.67%,特异度为60.32%,对CINⅡ及以上者的阴性预测值为98.70%。HPV-DNA16/58亚型阳性对CINⅡ及以上病变检出的敏感度为58.33%,特异度为69.05%。结论:HPV-DNA分型检测在ASC-US患者分层处理中有意义,对HPV-DNA分型检测高危阳性患者需行阴道镜检查,其余可用宫颈细胞学随诊。

Objective：To explore the clinical significance of HPV-DNA genotype detection in patients with atypical squamous cells of undetermined significance（ASC-US）. Methods：From January 2008 and January 2010,138 cases received cervical cytological screening and HPV-DNA genotype detection in the hospital,and their cervical cytological result was ASC-US,the related data of 138 cases were analyzed. Results：Among 138 cases with ASC-US,61 cases were found with positive high risk subtype of HPV-DNA,accounting for 44.20%,46 cases were found with positive HPV-DNA16 or（and） HPV-DNA 58,accounting for 33.33% of the total cases and 75.41% of the positive high risk cases.The sensitivity and specificity of positive high risk HPV-DNA16/58 subtypes for detection of CINⅡ and above lesions were 58.33% and 69.05%,respectively. Conclusion：HPV-DNA genotype detection is of significance in stratified treatment of cases with ASC-US.For the cases with positive high risk HPV-DNA subtype,colposcopy is necessary,the other cases can be followed up by cervical cytological test