普贝生应用于足月胎膜早破计划分娩

Application of Propess in programmed delivery of full-term premature rupture of membrane

目的:探讨地诺前列酮(普贝生)用于足月胎膜早破患者计划分娩的有效性及安全性。方法:选取计划分娩的单胎初产妇140例,均有计划分娩指征,分为实验组(胎膜早破组)59例、对照组(胎膜未破组)81例。观察用药前后宫颈Bishop评分,用药至临产及分娩的时间、用药24 h阴道分娩率,改用缩宫素使用率,手术产率,新生儿Apgar评分及有无不良反应,产后24 h出血量、产褥感染情况。结果:两组的宫颈Bishop评分、用药后至出现规律宫缩,总产程,产后出血,产褥病率及Apgar评分,新生儿窒息率差异均无统计学意义。结论:普贝生用于足月胎膜早破者计划分娩是有效和安全的,对临床有着重要的指导意义。

Objective：To explore the effectiveness and safety of dinoprostone（Propess） in programmed delivery of full-term premature rupture of membrane（PROM）. Methods：140 primiparous women of single pregnancy who adopted programmed delivery were selected and divided into experimental group（PROM group,59 cases） and control group（non-PROM group,81 cases）,all the women had indicators of programmed delivery;the indexes including cervical Bishop scores before and after treatment,the time between treatment and delivery,vaginal delivery rate at 24 hours after treatment,the utilization rate of oxytocin,the rate of operative delivery,neonatal Apgar score and adverse reactions,the amount of blood loss at 24 hours after delivery and the situation of puerperal infection were observed. Results：There was no significant difference in cervical Bishop score,the time between treatment and the appearance of regular uterine contraction,the total labor course,the amount of blood loss after delivery,the rate of puerperal infection,neonatal Apgar score and the incidence of neonatal asphyxia between the two groups. Conclusion：Propess is effective and safe in programmed delivery of full-term PROM,which has important clinical significance