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P63基因研究的相关进展 被引量：2

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摘要 大量研究表明抑癌基因P53在人类50%以上的肿瘤中发生突变,P53具有的主要功能包括细胞周期调控、DNA修复、血管形成抑制、转移抑制、细胞凋亡等。Schmale和Yang等分别在1997年和1998年相继从大鼠和人类中发现了p53的同源基因p73和p63。p63虽然在序列和结构上与p53具有很高的同源性，
作者 廖常莉 欧册华
机构地区 泸州医学院附属医院麻醉科
出处 《泸州医学院学报》 2011年第2期205-207,共3页 Journal of Luzhou Medical College
关键词 P63基因 细胞周期调控 血管形成抑制 DNA修复 基因p73 抑癌基因 转移抑制 细胞凋亡
分类号 R730.1 [医药卫生—肿瘤]
  • 相关文献

参考文献25

  • 1Schmale H,Bamberger C. A novel protein with strong ho- mology to the tumor suppressor p53[J].Oncogene,1997;15 (11):1363.
  • 2Yang AN, Kaghad M,Wang YM,et al.p63,a p53 homolog at 3q27-29,encodes multiple products with tranctivating, death-inducing,and dominant-negative activities [J].Mol Cell, 1998;2(3):305.
  • 3Osada M,Ohba M,Kawahara C,et al.Cloning and funci- tional analysis ofhuman pSI,which stiucturally and func- tionally resembles p53[J].Nat, Med,1998;4(7):839.
  • 4Mai M, Huang H,Reed C,et al.Genomic organization and mutation analysis of p73 in oligodendrogliomas with chromosome 1 parm deletions[J]. Genomics, 1998;51(3): 359.
  • 5Kaghad M,Bonet H,Yang A,et al.Monoallelically expressed gene related to p53 at 1p36,a region frequenfly deleted in neuroblastoma and other human cancer[J].Cell,1997;90(4): 809.
  • 6IkawaS,Nakagawara A,Lkawa Y.P53 family genes:structural cumparison,expresson and mutation[J].CeU Death and Defferentiation, 1999 ;6(12):1154.
  • 7Levrero M ,Laurenzi VD,Costanzo A,et al.Structure,fhnc- tion and regulation of p63 and p73[J].Ce 11 death and Def- ferenfiafion, 1999;6 (12): 1146.
  • 8Schuhz J,Ponting CP ,Hofinarm K,et al. SAM as a protein interaction domain involved in developmental regulation [J]. Protein Sci, 1997,6:249.
  • 9Thanos CD,Bowie JU.P53 family members p63 and p73 are SAM domain-containing proteins [J].Protein Sci,1999; 8:1708.
  • 10Mills AA,Zheng B,Wang X J,et al.p63 is a p53 homologue required for limb and epidermal mo rphogenesis[J].Nature, 1999;398(6729):708.

二级参考文献5

同被引文献12

  • 1Canman CE, Chen CY, Lee MH, et al. DNA damage responses: p53 induction, cell cycle perturbations, and apoptosis[J]. Cold Spring Harb Symp Quant Biol, 1994, 59: 277-86.
  • 2Yang A, Kaghad M, Wang Y, et al. p63, a p53 homolog at 3q27 -29, encodes multiple products with transactivating, death-indu- cing, and dominant-negative activities[J]. Mol Cell, 1998, 2(3) : 305-16.
  • 3Park BJ, Lee SJ, Kim JI, et al. Frequent alteration of p63 ex- pression in human primary bladder carcinomas[J]. Cancer Res, 2000, 60(13): 3370-4.
  • 4Sunahara M, Shishikura T, Takahashi M, et al. Mutational anal- ysis of p51A/TAp63gamma, a p53 homolog, in non-small cell lung cancer and breast cancer[J]. Oncogene, 1999, 18(25) : 3761 -5.
  • 5Mendonca LM, dos Santos GC, dos Santos RA, et al. Evaluation of eurcumin and cisplatin-induced DNA damage in PC12 cells by the alkaline comet assay[J]. Hum Exp Toxicol, 2010, 29 (8): 635-43.
  • 6Ishida S, Yamashita T, Nakaya U, et al. Adenovirus-mediated transfer of p53-related genes induces apoptosis of human cancer cells[J]. Jpn J Cancer Res, 2000, 91(2) .. 174-80.
  • 7Wang BY,Gil J,Kaufman D,et al.P63 in pulmonary epithelium,pulmonary squamous neoplasms,and other pulmonary tumors[J].Hum Pathol,2002,33(9):921-926.
  • 8Mukhopadhyay S,Katzenstein AL.Subclassification of non-small cell lung carcinomas lacking morphologic differentiation on biopsy specimens:Utility of an immunohistochemical panel containing TTF-1,napsin A,p63,and CK5/6[J].Am J Surg Pathol,2011,35(1):15-25.
  • 9Yang A,Kaghad M,Wang Y,et al.p63,a p53 homolog at 3 q27-29,encodes multiple products with transactivating,death-inducing,and dominant-negative activities[J].Mol Cell,1998,2(3):305-306.
  • 10王冬梅,陈勃江,李为民,李静,陈文彬.肺癌危险因素的Meta分析[J].中国循证医学杂志,2010,10(12):1446-1449. 被引量：45

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泸州医学院学报
2011年 第2期

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