熊去氧胆酸治疗原发性硬化性胆管炎:附病例报告

Study on Ursodeoxycholic Acid in Treatment of Primary Sclerosing Cholangitis

原发性硬化性胆管炎(PSC)是一种原因不明的胆汁淤积性肝病,遗传易感性和个人环境因素可能对其发病起作用。熊去氧胆酸有利于胆汁淤积性肝病治疗,且有证据证明,在PSC中应用高剂量(±20 mg/kg)熊去氧胆酸可能比一般剂量更有效。本文报道一例熊去氧胆酸治疗PSC的临床效果,结合文献进行分析。

Primary sclerosing cholangitis（PSC） is an unexplained cholestatic liver disease,and genetic predisposition and environmental factors are possibly responsible for it.Ursodeoxycholic acid（UDCA）is beneficial for cholestatic liver diseases.In primary sclerosing cholangitis（PSC）,evidences show that high doses（±20 mg/kg）of UDCA may be more effective than average doses.This article reports on the clinical effect of UDCA in the treatment of PSC with analysis based on literature.