胆道梗阻病人胆汁中肿瘤标志物的变化及临床意义

Diagnositc value of preoperation bile multi-biomarker detection for maliganency biliary obstruction

目的探讨胆汁癌胚抗原（CEA）、CA19-9、CA125检测在胆道梗阻病人中的临床意义。方法选择经手术或（和）病理检查证实的胆道恶性病变致胆道梗阻32例（胆道恶性病变组），与同期胆道良性病变致胆道梗阻36例（胆道良性病变组），分别检测其血清和胆汁中的CEA、CA19—9、CA125含量，并对其进行分析比较。结果胆道恶性病变组病人胆汁中CEA、CA19—9、CA125的含量与其在血清中的含量比较，差异均有统计学意义（P〈0．01）。而胆道良性病变组胆汁中CEA、CA19—9、CA125含量与血清中检测结果比较，差异均没有统计学意义（P〉0．05）。结论胆汁中CEA、CA19—9、CA125测定对于胆道良、恶性病变所致胆道梗阻的鉴别有一定的临床意义。

Objective To explore the preoperative diagnostic values of carcinoembryonic antigen （CEA） ,CA19-9,CA125 in bile. Methods Thirty two cases of malignant biiiary obstruction as experi- mental groups and 36 cases of benign biliary obstruction as control group were selected. The levels of CEA,CA19-9 and CA125 in serum and bile were detected and compared. Results The levels of CEA, CA19-9 and CA125 in bile were significantly higher than those in serum in experimental group（P〈 0. 01 ）. The levels of CEA,CA19-9 and CA125 in bile and serum had no statistically significant differ ence in control group（P〉0. 05）. Conclusion The determination of CEA, CA19-9 and CA125 in bile has significant values in preoperative differential diagnosis between the malignant biliary straitness and the benign biliary straitness.