血浆载脂蛋白与冠心病的相关性研究

目的探讨apoB100/apoA1水平升高与冠心病的相关性。方法入选2007年1月～2009年7月因胸痛入院的患者,其中经冠脉造影确诊为冠心病的患者208例,设为冠心病组;非冠心病患者152例,为对照组。以免疫透射比浊法测定Lp(a)、载脂蛋白A1、载脂蛋白B100。以氧化酶法测甘油三酯、总胆固醇、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)。计算apoB100/apoA1比值,LDL-C/HDL-C比值,进行相关分析。结果 (1)冠心病组的LP(a)、TC、TG、LDL-C、HDL-C、ApoA1、ApoB100、LDL-C/HDL-C、apoB100/apoA1比值分别为(261.85±187.29)mg/L、(4.28±0.87)mmol/L、(1.61±1.03)mmol/L、(2.40±0.60)mmol/L、(1.17±0.26)mmol/L、(1.09±0.28)mmol/L、(0.77±0.24)mmol/L、2.12±0.59、0.75±0.32,而对照组相应值分别为(244.43±166.13)mg/L、(4.29±0.84)mmol/L、(1.65±0.99)mmol/L、(2.37±0.56)mmol/L、(1.19±0.26)mmol/L、(1.19±0.70)mmol/L、(0.73±0.25)mmol/L、(2.08±0.65)、(0.68±0.31)。冠心病组apoB100/apoA1比值高于对照组(P<0.05)。(2)相关分析显示apoB100/apoA1比值升高与诊断冠心病有明显的相关性(r=0.157,P=0.029)。结论 apoB100/apoA1是诊断冠心病最显著的独立危险因素。

Objective To explore the correlation between the ratio of apolipoproteinB100/apolipoproteinA1 and coronary artery disease（CAD）.Methods A total of 360 patients underwent coronary angiography in our department from January 2007 to July 2009 due to chest pain were included,208 cases（57.8%） were diagnosed as CAD and the remaining 152 non-CAD patients（42.2%） served as control.Lp（a）,apolipoproteinA1,apolipoproteinB100 were detected by immunoturbidimetry method,triglyceride,total cholesterol,high density lipoprotein cholesterol and low density lipoprotein cholesterol were measured by enzymatic approach.LDL-C/HDL-C ratio and apoB100/apoA1 ratio were calculated,correlation analysis was performed.Results（1） The values of LP（a）,LDL-C,ApoB100,the raio of LDL-C/HDL-C in CAD group were higher [（261.85±187.29） mg/L,（2.40±0.60）mmol/L,（0.77±0.24）mmol/L,and 2.08±0.65] compared to those in control group [（244.43±166.13）mg/L,（2.37±0.56）mmol/L,（0.73±0.25）mmol/L and 2.08±0.65],but none were statistically significant（P0.05）.And the ratio of apoB100/apoA1 were significantly higher in CAD group（0.75±0.32）compared to that in control group [0.68±0.31,P0.05].（2）Spearman correlation analysis indicated that the ratio of apoB100/apoA1（r=0.157,P =0.029）was the most powerful independent risk factor for diagnosing coronary artery disease.Conclusion The ratio of apoB100/apoA1 is the most powerful independent risk factor for diagnosing coronary artery disease.