伽玛刀治疗原发性三叉神经痛长期随访分析报告

Long-term Follow-up analysis of gamma knife Radiosurgery for primary trigeminal neuralgia

目的分析伽玛刀治疗原发性三叉神经痛的远期疗效、生活质量的改善及并发症的发生情况。方法选择2004年1月~2009年1月间,89例原发性三叉神经痛患者接受伽玛刀治疗,并进行长期随访（最长5年,最短1.5年,平均3年）,详细记录其疼痛的缓解情况及并发症情况,通过生活满意度指数-A（life satisfaction index A）了解伽玛刀术后患者的主观感受。结果治疗后近期随访（少于2年）有效率96%,2年以上的长期随访有效率85%,复发率12%,长期随访并发症发生率31%,此类并发症被患者接受。结论伽玛刀治疗原发性三叉神经痛疗效肯定,而且显著改善患者的生活质量,并发症的发生率低且较轻,可作为三叉神经痛患者的主要治疗方法。

Objective To analyse the treatment effect,quality of life and complications of gamma knife radiosurgery for primary trigeminal neuralgia after long-term follow-up.Methods Between January 2004 and January 2009,89 patients with primary trigeminal neuralgia were treated with gamma knife radiosurgery,and were follow-up for long-term（the longest 5 years,the shortest 1.5 years and 3 years average）,and recorded in detail their degree of pain relief and complications suffered,and meanwhile patients treatment outcomes were also evaluated by life satisfaction index A（LSI-A）.Results The percentage of patients who achieved pain free or relieved significantly was 96% after treatment less than 2 years,85% for the long-term follow-up period of more than 2 years.The reoccurrence rate was 12%,The long-term complications occurred in 31% of patients,but all were light and could be accepted by patients.Conclusion Gamma knife radiosurgery can be the first treatment option for patients with primary trigeminal neuralgia.It yields good results for long-term,as well as improved quality of life and complications were light and occurred in low rate.