摘要
炎症性肠病(inflammatory bowel disease,IBD)是一组病因未明的慢性肠道炎症性疾病,包括溃疡性结肠炎(ulcerative colitis,UC)和克罗恩病(Crohn's disease,CD).IBD的病因仍不明确,传统治疗主要是控制活动性炎症和调节免疫紊乱,常用药物包括5-氨基水杨酸、糖皮质激素和免疫抑制剂等,部分病例最终需手术治疗.目前治疗IBD应针对多种发病机制,采取综合性措施.随着治疗研究的进一步发展出现了生物制剂、转基因方法、抗凝治疗、干细胞移植,使治愈IBD成为可能.其中干细胞移植是一种新兴的IBD治疗方法,近年来成为治疗研究领域的热点之一,本文就干细胞移植治疗IBD的研究现状及作用机制进行概述.
Inflammatory bowel disease （IBD） is comprised of ulcerative colitis and Crohn＇s disease and characterized by chronic inflammation of the intestinal tract. The etiology of IBD is still unknown. Traditional treatment mainly controls active inflammation and regulates immunologic derangements. Commonly used drugs include 5-aminosalicylic acid,glucocorticoid and immunosuppressant. Some cases of IBD require surgical treatment eventually. Due to multipe etiologies,IBD should be managed comprehensively. The appearance of biological agents,genetically modified methods,anticoagulant therapies,and stem cell transplantation therapies has made it more likely to cure IBD. Stem cell transplantation represents a new type of treatment for IBD. In this article,we review the role of stem cell transplantation in the treatment of IBD.
出处
《世界华人消化杂志》
CAS
北大核心
2010年第35期3772-3777,共6页
World Chinese Journal of Digestology
关键词
炎症性肠病
干细胞移植
治疗
Inflammatory bowel disease
Stem cell transplantation
Treatment
