肠易激综合征国内实验研究现状的调查

Irritable bowel syndrome:current state of experimental research in China

目的:系统回顾性分析目前国内肠易激综合征(IBS)发病机制及建模研究.方法:通过检索万方医学数据库和中国知识资源综合数据库的资源目录,寻找符合要求的实验研究文献,结合国际研究进展分析所搜集的数据.结果:神经递质和神经肽在国内IBS实验中研究比例较大,约62.86%;单一方法建模与两种方法联合建模的应用比例相近,而多种方法综合建模应用比例较低;尚缺乏模型大鼠性别、年龄差异对IBS研究结果影响的客观评价.结论:建模方法和研究内容多样,没有达成统一的共识.但已经从单一的方法建模逐渐向多种方法联合建模的方式转变,试图建立能更好模拟临床患者的IBS综合模型以进行多机制的研究.

AIM：To conduct a systematic review examining the current state of experimental research of irritable bowel syndrome （IBS） in China. METHODS：IBS is a functional disorder of the gastrointestinal tract. Although numerous studies have investigated the pathophysiologic processes underlying IBS,the mechanisms underlying the pathogenesis of IBS remain poorly understood. In the present study,the Wanfang Med Online and China Knowledge Resource Integrated Database were searched to retrieve relevant literature to find reported animal models of IBS and identify factors affecting the pathogenesis of IBS. RESULTS：Approximately 62.86% of IBS-related studies investigated the role of neurotransmitters and neuropeptides in IBS. Animal models of IBS were developed frequently by a single method or combined use of two methods,and rarely by combined use of multiple methods. There have been few studies conducting objective evaluation of the impact of animal gender and age on research findings obtained from animal models of IBS. CONCLUSION：Researchers have not yet reached a uniform consensus about IBS-related experimental contents and the methods for development of animal models of IBS. More researchers tend to develop animal models of IBS by combined use of multiple methods with efforts to more truly mimic human IBS.