Sphygmocor脉搏波分析系统检测新疆和田维吾尔族正常人群中心动脉反射波增强指数(英文)

Central arterial augmentation index in Uygur health adults from Hetian,Xinjiang Detection by Sphygmocor pulse wave analysis system

背景:动脉僵硬度是心血管疾病的独立危险因素。中心动脉反射波增强指数(augmentation index,AIx)是反映全身动脉僵硬度的重要指标。目的:研究新疆和田维吾尔族正常人群AIx,并进一步分析影响AIx的因素。方法:选取新疆和田地区559名维吾尔族正常人群(男251名,女308名),平均年龄(44.95±11.87)岁。所有研究对象均进行问卷调查、一般体格检查及血液生化检测,采用Sphygmocor脉搏波分析系统检测中心动脉收缩压及AIx。采用Pearson相关分析和偏相关分析进行两两相关分析,采用多元逐步回归分析AIx的影响因素。结果与结论:女性AIx值高于男性,且AIx与年龄呈正相关(男:r=0.548,女:r=0.405,P<0.05),在校正其他影响因素后,AIx与年龄仍呈正相关(男:r=0.182,女:r=0.234,P<0.05)。多元逐步回归显示中心动脉收缩压、收缩压、性别、年龄、C-反应蛋白是新疆维吾尔族AIx的影响因素。中心动脉收缩压、收缩压、年龄、体质量、C-反应蛋白是男性AIx的影响因素;中心动脉收缩压、收缩压、年龄、身高、C-反应蛋白是女性AIx的影响因素。说明在新疆维吾尔族正常人群中,AIx女性高于男性,且与年龄相关,中心动脉收缩压、收缩压和C-反应蛋白也是新疆维吾尔族人群AIx的影响因素。

BACKGROUND：Arterial stiffness is an independent risk factor for cardiovascular disease. Augmentation index （AIx） is an important marker which reflects the systemic arterial stiffness. OBJECTIVE：To investigate AIx and the affecting factors in Xinjiang Uygur health adults. METHODS：A total of 559 healthy adults （251 males and 308 females） with a mean age of （44.95±11.87） years were selected from Hetian,Xinjiang Uygur Autonomous Region. The following indexes of all subjects were measured,including questionnaire,physical examination,blood biochemistry and C-reactive protein （CRP）. Central systolic blood pressure （cSBP） and central AIx were measured by Sphygmocor. Pearson correlation and partial correlation analysis were used for two-group analysis of correlation,and multiple regression analysis was used to analyze influential factors for AIx. RESULTS AND CONCULUSION：AIx was greater in female than in male and was positively related to age in both sexes （male：r=0.548,female：r =0.405,P 0.05）,as well as adjusted other influential factors （male：r=0.182,female：r =0.234,P 0.05）. Multiple regression analysis showed that cSBP,systolic blood pressure （SBP）,sex,age and CRP were main factors which affected AIx in Uygur healthy adults. cSBP,SBP,age,body mass and CRP were main factors which affected AIx in the male,while cSBP,SBP,age,height and CRP were main factors which affected AIx in the female. Results revealed that AIx was greater in female than in male which was positively related to age in both sexes. Age,cSBP,SBP and CRP were main factors that affected AIx in Xinjiang Uygur healthy adults.