NSCLC患者血清TIMP-1和TIMP-2检测的临床价值分析

Diagnostic and prognostic value of serum TIMP-1 and TIMP-2 in patients with NSCLC

目的:探讨血清金属蛋白酶组织抑制剂-1(TIMP-1)和金属蛋白酶组织抑制剂-2(TIMP-2)水平在晚期非小细胞肺癌(NSCLC)诊断及疗效预后评价中的临床价值。方法:用酶联免疫吸附法(ELISA)检测26名健康人和20例良性肺病患者及82例晚期NSCLC患者化疗前后血清TIMP-1、TIMP-2水平,并作对比分析。结果:NSCLC组化疗前血清中TIMP-1、TIMP-2水平均明显高于健康组(P<0.01)和良性肺病组(P<0.05)。NSCLC患者化疗有效组在化疗结束后7 d的血清TIMP-1、TIMP-2水平明显低于化疗前,P<0.01;化疗无效组化疗前、后血清TIMP-1、TIMP-2水平差异无统计学意义,P>0.05。单因素生存分析提示,血清TIMP-1水平与晚期NSCLC患者的预后有关,P<0.05。结论:NSCLC患者血清TIMP-1水平是一个有价值的肿瘤标志和预后指标,检测化疗前后血清TIMP-1、TIMP-2水平对评估化疗疗效有一定的临床意义。

OBJECTIVE：To investigate the diagnostic and prognostic value of serum tissue inhibitor of metalloproteinases-1（TIMP-1） and TIMP-2 in patients with advanced non-small cell lung cancer（NSCLC）patients.METHODS：Serum TIMP-1 and TIMP-2 levels were detected in control groups（26 normal people,20 lung bengin lesion patients） and 82 advanced NSCLC patients before and after chemotherapy by ELISA method.RESULTS：Serum TIMP-1 and TIMP-2 levels in NSCLC group were significantly higher than those in control groups（normal people,P0.01;lung bengin lesion patients,P0.05）,Serum TIMP-1 and TIMP-2 levels in patients who had effective response to chemotherapy on the 7th post-chemotherapy day was significantly lower than those before chemotherapy（P0.01）.There were no significant changes of the serum TIMP-1 and TIMP-2 levels in non-responders after chemotherapy（P0.05）.The analysis of single factor revealed that serum TIMP-1 levels were significantly related to the prognosis of advanced NSCLC（P0.05）.CONCLUSIONS：Serum TIMP-1 level in NSCLC may be a useful tumor marker and prognostic factor.The variation of serum TIMP-1 and TIMP-2 levels after chemotherapy has clinical significance in estimating the effect of chemotherapy.