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p73与肿瘤相关性的研究进展 被引量：3

Advances in correlation between p73 and tumours
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摘要 目的:总结p73在肿瘤发生发展过程中的作用及其在肿瘤防治领域的研究现状。方法:应用PubMed及CNKI期刊全文数据库检索系统,以"p73"为关键词,检索得到1997-01-2009-06的相关文献共1 560篇,其中中文文献318篇,英文文献1 242篇,纳入标准:1)p73的结构特征;2)p73的功能;3)p73与肿瘤的关系。根据纳入标准,选择30篇中、外文核心期刊作为参考文献。结果:p73的功能可能取决于TA亚型与DN亚型的比例,且与家族成员间网络化的相互作用,p73所受应激因素,所处细胞环境,组织类型及肿瘤类型等相关。结论:p73与肿瘤的发生发展密切相关,在肿瘤防治领域有广泛的应用前景。 OBJECTIVE：To summarize the functions of p73 in tumours and its role in cancer prevention and therapy.METHORDS：Based on PubMed and CNKI journal full-text database retrieval systems,literature was searched with the key word of ＂p73＂ from January 1997 to June 2009,obtaining a total of 1 560 articles,318 in Chinese and 1 242 in English.Choice criteria：1）the characteristics of structure about p73;2）the function of p73;3）the correlation between p73 and tumors.By extraction according to the choice criteria,30 papers were synthesized finally.RESULTS： The functions of p73 may depend on the ratio of TA isform and DN isform,which may also be in response to the complex network interactions within the p53 family,the stress factors,the cell context,the type of tissue and tumour.CONCLUSION： p73 is high associated with tumours and full of significance for anti-cancer therapy.
作者 吴炜景 赵亚刚
机构地区 广州军区广州总医院消化内科
出处 《中华肿瘤防治杂志》 CAS 2010年第21期1788-1791,共4页 Chinese Journal of Cancer Prevention and Treatment
关键词 基因 p73 肿瘤 细胞凋亡 gene p73 neoplasms apoptpsis
分类号 R730.2 [医药卫生—肿瘤]
  • 相关文献

参考文献30

  • 1Deyoung M P, Ellisen L W. p63 and p73 in human cancer: defining the network[J] . Oncogene,2007,26(36) :5169-5183.
  • 2Davison T S, Vagner C, Kaghad M, et al. p73 and p63 are homotetramers capable of weak heterotypic interactions with each other but not with p53[J].J Biol Chem, 1999,274 (26) : 18709-18714.
  • 3Kaghad M,Bonnet H, Yang A, et al. Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers[J]. Cell,1997,90(4) :809- 819.
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  • 5Tanaka Y, Kameoka M, Itaya A, et al. Regulation of HSF1 -responsive gene expression by N-terminal truncated form of p73alpha [J]. Biochem Biophys Res Commun,2004,317(3) :865-872.
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同被引文献41

  • 1张志平,姜冠潮,王俊.小分子干扰RNA特异性抑制人胰腺癌细胞株PANC-1突变型K-ras基因表达的探讨[J].中国肿瘤临床,2006,33(19):1081-1084. 被引量：5
  • 2Spitz MR, Wei Q, Dong Q, et al. Genetic susceptibility to lung cancer:the role of DNA damage and repair[J]. Cancer Epidemiol Biomarker Prey, 2003,12(8) :689-698.
  • 3Moll UM, Sladc N. p63 and p73: roles in development and tumor formation [J]. Mol Cancer Res, 200,1, 2(7)= 371 386.
  • 4Pozniak CD, Radinovic S, Yang A, et al. An anti lpoptotic role for the p53 family member, p73, during development neuron death [J].Science, 2000, 289(5477): 304 306.
  • 5Kaghad M, I~onneI H, Yang A, et aL. Monoallelically expressed gene related to p53 at 1 p36,a region frequently deleted in neuroblastoma and other human cancer [J] Cell, 1997, 90(4): 809-819.
  • 6Li Q, Alhan ES, Wei M, et al. TP73 allelie expression in hu man brain and allele frequencies in Alzheimer's disease[J]. BMC Med Genet, 2004,5:14.
  • 7Li G,Wang LE,Chamberlain RM, et al. p73 G4C1,1 to A4T14 polymorphismand risk of lung cancer [J]. Cancer Res, 2004, 64 (19) :6863 -6866.
  • 8Choi JE,Kang HG,Chae MH, et al. No association between p73 G4C14 to A4T14 polymorphism and the risk of lung cancer in a Korean population [J].Biochemical Genetics,2006,44(ll 12): 543- 550.
  • 9Matthew B,Wu X,Wci Q,et al. Combined effects of the p53 and p73 polymorphism on lung cancer risk [J]. Cancer Epidemiol Bi- omarkers Prev,2006,15(1) :158-161.
  • 10Hu Z, Miao X,Ma H,et al. Dinucleotide polymorphism of p73 gene is associated with a rcducecl risk of lung cancer in a Chinese population [J].Int J Cancer,2005,114(3):455 -460.

引证文献3

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中华肿瘤防治杂志
2010年 第21期

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