4Baccarelli A, Bollati V. Epigenetics and environmental chemicals[J]. Curr Opin Pediatr, 2009,21 (2) :243-251.
5Zieeh D, Franco R, Pappa A, et al. The role of epigeneties in environmental and occupational carcinogenesis [J]. Chem Biol Interact, 2010, 188 ( 2 ) : 340-349.
1Jaenisch R, Bird A. Epigenetic regulation of gene expression:how the genome integrates intrinsic and environmental signaJs.Nat Genet,2003.33:245-254.
2Grewal SI, Moazed D. Heterochromatin and epigenetic control of gene expression. Science,2003. 301 : 798-802.
3Beck S, Olek A. The Epigenome: Molecular Hide and Seek.Wiley-VCH GmbH & Co. KgaA.2003.
4Wyatt GR. Recognition and estimation of 5-methylcytosine in nucleic acids. J Biochem, 1951.48 : 581-584.
5Strahl BD, Allis C. The language of covalent histone modifications. Nature, 2000.403 : 41-45.
6Berger SL. Histone modifications in transcriptional regulation.Curr Opin Genet Dev,2002. 12:142-148.
7Mizuguchi G, Shen X, Landry J, et al. ATP-driven exchange of histone HZAZ variant catalyzed by SWR1 chromatin remodeling complex. Science, 2003.16 : 343-348.
8Ryan A. Irvine, Iping G. Lin, et. al. DNA Methylation Has a Local Effect on Transcription and Histone Acetylation. Mol Cell Biol,2002. 22,6689-6696.
9Denison MS, Nagy SR. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals, 2003.43 : 309-334.
10Metivier R, Penot G, Hubner MR, et al. Estrogen receptor-a directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell, 2003.115:751-763.
1Vandenberg LN,Maffini MV,Sonnenschein C,et al. Bisphenol-Aand the great divide : A review of controbersies in the field of endo-crine disruption[ J]. Endocrine Reviews, 2008 ,30( 1 ) :75-95.
2Naciff JM, Khambatta ZS,Reichling TD, et al. The genomic re-sponse of Ishikawa cells to bisphenol A exposure is dose- and time-dependent [ J] .Toxicology, 2010,270(2010):137-149.
3Adachi S, Yamada SJ,Takatsu Y,et al. Involvement of anterov-entral periventricular Metastin/Kisspeptin neurons in estrogen posi-tive feedback action on luteinizing hormone release in female rats[J]. J. Reprod Dev, 2007,53(2) :369-380.
4Navarro VM, Castellano JM, Femdndez-Femdndez R, et al. De-velopmental and hormonally regulated messenger ribonucleic acidexpression of Kiss-1 and its putative receptor, GPR54, in rat hypo-thalamus and potent luteinizing hormone-releasing activity of Kiss-1peptide[ J]. Endocrinology, 2004,145( 10) :4565-4574.
5Quennell JH, Rizwan MZ, Relf HL, et al. Developmental and ste-roidogenic effects on the gene expression of HFamide related pep-tides and their receptor in the rat brain and pituiary gland[ J]. JNeuroendocrinol,2010,22(4) :309-316.
6Stafford LJ, Xia C, Ma W, et al. Identification and characteriza-tion of mouse metastasis-suppressor Kissl and its G-protein-coupledreceptor[ J]. Cancer Res, 2002,62( 19) :5399-5404.
7Messager S, Chatzidaki EE, Ma D, et al. Kisspeptin directly stim-ulates gonadotropin-releasing hormone release via G protein-coupledreceptor 54 [ J]. Proc Natl Acad Sci USA, 2005 ,102 (5 ) : 1761-1766.
8Tsutsui K, Saigoh E, Ukena K, et al. A novel avian hypothalamicpeptide inhibiting gonadotropin release [ J ]. Biochem Biophys ReaCommun, 2000,275(2) :66l-667.
9Rizwan MZ, Poling MC, Corr M, et al. RFamide-related peptide-3 receptor gene expression in GnRH and Kisspeptin neurons andGnRH-dependent mechanism of action [ J ]. Endocrinology, 2012,153(8) :3770-3779.
10Kriegsfeld LJ, Mei DF, Bentley GE, et al. Identification and char-acterization of a gonadotropin-inhibitory system in the brains ofmammals [ J ] , Proc Natl Acad Sci USA,2006,103 ( 7 ) : 2410-2415.