双膦酸盐药物长期应用对显微损伤和骨力学性能的影响

Effect of long-term use of bisphosphates on microdamage and mechanical properties of bone

双膦酸盐类药物作为治疗骨质疏松的一线药物,可以通过降低骨转换来增加骨密度,防止骨折的发生,在临床已经有较长期应用。最近研究表明,双膦酸盐类药物在抑制骨重建的同时,会影响显微损伤的修复,导致显微损伤的积聚和骨质量的下降,进而降低骨的韧性,削弱骨的力学性能。已有临床报告指出,骨质疏松病人使用双膦酸盐后有可能发生非创伤性骨折。本文综述了双膦酸盐类药物对骨显微损伤和骨力学性能的影响。

Bisphosphates as a first-line preferred drug for curing osteoporosis has been used for a long time in clin-ic since it can inhibit the bone remodeling to decrease the risk of bone fracture and increase the bone density.But recent studies show that bisphosphates could cause the accumulation of microdamage to decrease bone quality.The long-term use of bisphosphates may reduce the bone toughness and weaken the mechanical properties of bone.Some clinical reports have indicated that patients with osteoporosis tend to have non-traumatic fractures af-ter their use of bisphosphates.This article will review the effect of bisphosphates on the microdamage and me-chanical properties of bone.