丹参对皮瓣缺血再灌注损伤的影响及机制

Effect and mechanism of salvia miltiorrhiza on flap ischemia-reperfusion injury

背景:大量研究资料表明皮瓣缺血再灌注损伤是一系列复杂的病理生理过程,其具体机制尚未完全阐明。而中药丹参作为整形外科皮瓣移植后的常用药物,具有减轻缺血再灌注损伤、减少皮瓣坏死的作用。目的:综述丹参对皮瓣缺血再灌注损伤保护作用机制的研究进展。方法:应用计算机检索Elsevier数据库和CNKI数据库中1980-01/2010-04关于丹参对皮瓣缺血再灌注损伤保护作用方面的文章,在标题和摘要中以"丹参,皮瓣,缺血再灌注损伤"或"salvia miltiorrhizae,flap,ischemia-reperfusion"为检索词进行检索。根据纳入标准选择50篇文献进行综述。结果与结论:关于丹参对防治心、肝、脑、肾、肠道等器官缺血再灌注损伤的研究较多,大量研究表明丹参可从细胞水平、基因水平、微循环方面,多条途径、多种机制减轻缺血再灌注损伤。但丹参对皮瓣缺血再灌注损伤的研究较少,其确切的作用机制目前尚不完全明确。因此关于丹参对皮瓣缺血再灌注损伤的保护作用机制将成为进一步的研究方向。

BACKGROUND：The flap ischemia-reperfusion injury is a complex pathophysiological process,but the specific mechanism is not yet clearly.The traditional Chinese medicine Danshen（salvia miltiorrhizae） has a role to reduce ischemia reperfusion injury and the necrosis of skin flap after flap transplanting.OBJECTIVE：To discuss the research progress of salvia miltiorrhizae on protects the flap from ischemia-reperfusion injury.METHODS：Elsevier database and CNKI was retrieved by computer with key words of ＂salvia miltiorrhizae,flap,ischemia-reperfusion＂ to search papers published between January 1980 and April 2010.Related papers addressing medical dressings were selected.According to inclusion criteria,50 literatures were selected in this study.RESULTS AND CONCLUSION：The studies regarding salvia miltiorrhiza preventing and treat heart,liver,brain,kidney,intestines and other organs ischemia-reperfusion injury are more,which shows that salvia miltiorrhiza may be from the cell level,gene level and micro-circulation,through numbers of channels,varieties of mechanisms to reduce ischemia reperfusion injury.But the studies on salvia miltiorrhiza protecting the flaps ischemia-reperfusion injury are fewer,and the exact mechanism is not entirely clear.Thus,the protective effect of salvia miltiorrhiza to flaps＇ ischemia-reperfusion injury need to be further explored.