组织工程化肌腱移植的进展

Progress of tissue-engineered tendon transplantation

背景:肌腱移植是重建损伤肌腱功能的主要手段,目用于肌腱移植的材料有自体肌腱、同异体肌腱、异种异体肌腱、人工肌腱、组织工程化肌腱等,但均有各自的缺点。目的:就近年肌腱缺损的自体和异体移植治疗进展进行总结,为组织工程修复肌腱损伤的研究提供理论基础。方法:由第一作者于2010-03应用计算机检索PubMed数据库、万方数据库和维普数据库相关文献。英文资料的检索时间为2000/2010-03;中文资料的检索时间为2002-01/2010-03。英文检索词为"tendon tissue engineering,tendon allograft,transplantation";中文检索词为"肌腱,损伤修复,移植,自体,异体,组织工程"。纳入标准:①肌腱损伤修复的发展史。②自体或异体肌腱移植治疗肌腱损伤的研究。③动物实验及临床应用。阅读标题和摘要进行筛选,共纳入30篇用于文章分析。结果与结论:随着组织工程研究的发展,利用细胞生物学、分子生物学及生物材料学技术构建组织工程复合物已成为是肌腱移植材料的研究热点。但异体肌腱移植后的排斥反应、粘连及转归情况等,尚需动物实验及临床研究做进一步观察和验证。

BACKGROUND：Tendon transplantation is a major means for reconstructing injured tendon.Currently,autoallergic tendon,allogeneic tendon,xenogeneic allogeneic tendon,artificial tendon,tissue-engineered tendon are widely used with each characteristics.OBJECTIVE：To summarize the treatment progress of currently used tendon transplantations for tendon defects,and to provide theoretical basis for tissue-engineered tendon.METHODS：Databases of PubMed,Wangfang and VIP were searched by the first author using key words of tendon tissue engineering,tendon allograft,transplantation＂ both in Chinese and English.Inclusive criteria：①Development history of repair of tendon injury.②Autoallergic tendon or allogeneic tendon transplantation for tendon injury.③Animal experiment and clinical application.A total of 30 documents were included in this paper.RESULTS AND CONCLUSION：With the development of tissue engineering,tissue-engineered tendon,which constructed by utilizing cell biology,molecular biology and biological materials,has aroused increasing attention.However,further animal experiment and clinical researches are required to study the rejection,adhesion and prognosis following allogeneic tendon transplantation.