原发性肾病综合征抗心磷脂抗体的检测

Clinical significance of anticardiolipin antibody in patients with primary nephrotic syndrome

目的：探讨原发性肾病综合征（NS）抗心磷脂抗体（ACL）检测的意义.方法：检测本院肾内科52例原发性肾病综合征患者和20例正常人ACL抗体.测定52例NS患者血栓素B2（TAB2）,抗凝血酶Ⅲ抗体（AT-Ⅲ）,血小板计数（P1t）,血清白蛋白（AIB）和胆固醇（CH）,甘油三酯（TG）,尿蛋白定量及尿FDP.结果：NS组ACL阳性率（34.6%）明显高于对照组（5%）.ACL组阳性（264.62±87.28）TAB2较阴性者（113.12±32.82）明显升高（P＜0.05）,CH、TG、尿蛋白定量及尿FDP明显升高（P＜0.01）,AT-Ⅲ明显降低.18例ACL阳性患者静脉血栓形成8例,34例ACL阴性患者2例血栓形成,有显著差异.结论：ACL在原发性肾病综合征的发病及发展中可能有重要作用,可作为NS患者血栓形成的一项预测.

Objective：To evaluate the clinical significance of anticardiolipin antibody （ACL） in patients with primary nephrotic syndrome（NS）. Methods： The anticardiolipin antibody was detected in 52 patients with primary nephrotic syndrome and 20 healthy persons. The serum thromboxane B2 （ TAB2 ）, Anti-Thrombin Ⅲ （ AT - Ⅲ ）, platelet count, serum album （ AIB）, serum cholesterol （ CH）, serum triglycerides （ TG ）, urinetotalprotein, urinary FDP were examined in 32 patients with NS. Results：The serum ACL, TAB, CH,TG and urinetotalprotein, urinary FDP increased significantly. In 18 patients with ACL positive,5 cases of renal vein thrombosis occurred, in 34 ACL negative patients ,2 cases of renal vein thrombosis occurred, the difference was significant. Conclusion：ACL plays an important in the pathogenesis and development of primary nephrotic syndrome.