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Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes 被引量：1

Real-time detection of the interaction between anticancer drug daunorubicin and cancer cells by Au-MCNT nanocomposites modified electrodes
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摘要 In this study,we have prepared the blending of gold nanoparticles-multiwalled nanotubes (Au-MCNTs) and then applied the new nanocomposites to modify the glassy carbon electrode (GCE) for highly sensitive detection of the interaction between anticancer drug daunorubicin (DNR) and cancer cells. Electrochemical analysis indicates that the Au-MCNT modified GCE shows high sensitivity and could track the real time response of cancer cells under DNR treatments. Therefore,this new nano-interface and Au-MCNT modified electrode could be explored as a rapid,highly sensitive,and convenient real-time detection strategy in cancer related research and would have prospect in other biomedical applications. In this study,we have prepared the blending of gold nanoparticles-multiwalled nanotubes （Au-MCNTs） and then applied the new nanocomposites to modify the glassy carbon electrode （GCE） for highly sensitive detection of the interaction between anticancer drug daunorubicin （DNR） and cancer cells. Electrochemical analysis indicates that the Au-MCNT modified GCE shows high sensitivity and could track the real time response of cancer cells under DNR treatments. Therefore,this new nano-interface and Au-MCNT modified electrode could be explored as a rapid,highly sensitive,and convenient real-time detection strategy in cancer related research and would have prospect in other biomedical applications.
作者 LI QingNing WU XiaoJing ZHAO Juan WU ChangYu WANG XueMei
机构地区 State Key Laboratory of Bioelectronics Southeast University Medical School
出处 《Science China Chemistry》 SCIE EI CAS 2011年第5期812-815,共4页 中国科学（化学英文版）
基金 supported by the National Natural Science Founda-tion of China (90713023 & 20675014) the Natural Science Foundation of Jiangsu Province (BK2008149) the Foundation of Talent Project and disci-pline project of Ningbo University (B00121104700 & XKL126) National High Technology Research and Development Program of China (2007AA022007) Doctoral Fund of Ministry of Education of China (20090092110028) National Basic Research Program of China (2010CB732404) Visiting Scholar Foundation of Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, China
关键词 纳米复合材料 修饰电极 实时检测 相互作用 柔红霉素 抗癌药物 癌细胞 癌症 pharmaceutical analysis electrochemical detection anticancer drugs gold nanoparticles multi-walled carbon nanotubes
分类号 TP391.41 [自动化与计算机技术—计算机应用技术] TB332 [一般工业技术—材料科学与工程]
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参考文献20

  • 1Jiang H,Wang XM.Highly sensitive detection of daunorubicin based on carbon nanotubes-drug supramolecular interaction. Electrochemistry Communications . 2009
  • 2Song M,Zhang RY,Dai YY,Gao F,Chi HM,Lv G,Chen BA,Wang XM.The in vitro inhibition of multidrug resistance by com- bined nanoparticulate titanium dioxide and UV irradiation. Biomate- rials . 2006
  • 3Sinha N,Yeow JT.Carbon nanotubes for biomedical applications. IEEE T Nanobiosci . 2005
  • 4Gewirtz D A.A critical evaluation of the mechanisms of action proposed for the antitumor effects of the anthracycline antibiotics adriamycin and daunorubicin. Biochemical Pharmacology . 1999
  • 5Sumio Iijima.Helical Microtubules of Graphitic Carbon. Nature . 1991
  • 6Iijima S,Ichihashi T.Single-shell carbon nanotubes of 1-nm diameter. Nature . 1993
  • 7Sun YP,Fu K,Lin Y,et al.Functionalized carbon nanotubes: properties and applications. Accounts of Chemical Research . 2002
  • 8Baughman RH,Zakhidov AA,de Heer WA.Carbon nanotubes-the route toward applications. Science . 2002
  • 9FA Fornari,JK Randolph,JC Yalowich,MK Ritke,DA Gewirtz.Interference by doxorubicin with DNA unwinding in MCF-7 breast tumor cells. Molecular Pharmacology . 1994
  • 10Song M,Guo DD,Pan C,Jiang H,Chen C,Zhang RY,Gu ZZ,Wang XM.Application of poly (N-isopropylacrylamide)-co-polystyrene nanofibers as an additive agent to facilitate the cellular uptake of an anticancer drug. Nanotechnology . 2008

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Science China Chemistry
2011年 第5期

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