盐酸纳洛酮治疗进展性缺血性脑卒中68例临床观察

Use of Naloxone Hydrochloride on Progressive Ischemic Stroke:A Clinical Observation of 68 Cases

目的探讨盐酸纳洛酮治疗进展性脑卒中临床疗效。方法 将136患者随机分为治疗组和对照组各68例,对照组给予常规对症治疗并口服肠溶阿司匹林;治疗组在对照组治疗基础上加用盐酸纳洛酮。结果治疗组总有效率91.18%,对照组总有效率77.94%,两组比较差异有统计学意义(P<0.05);治疗组治疗后血清hs-CRP水平测定及血液流变学各项指标变化均优于对照组,两组比较差异均有统计学意义(P<0.01或P<0.05)。结论进展性脑卒中患者应用盐酸纳洛酮治疗后血液流变学各项指标改善及血浆C-反应蛋白下降显著,神经功能缺损评分改善明显,临床疗效肯定,值得推广使用。

Objective To evaluate the clinical treatment effect of using naloxone hydrochloride on progressive stroke. Methods We divided 136 patients with spat random into a treatment group and a control group with 68 cases in each group. Routine symptomatic treatment was carried out to the control group,and the control group orally took enteric-coated aspirin;the treatment group additionally used naloxone hydrochloride on the basis of control group treatment. Results In the treatment group the total effective rate was 91.18%,in the control group the total effective rate was 77.94%, the two groups were compared,the difference had statistically significant （P〈0.05）;various index changes of serum hs-CRP level measurement and hemorheology of the control group after treatment were better than the control group,with a significant difference （P〈0.01 or P〈0.05）. Conclusion Various indexes of hemorheology of patients with progressive stroke can be improved and the plasma C-reactive protein is significantly decreased after treatment in treatment group,neurological deficit scores are improved significantly,the clinical effect is affirmative,and the method is worthy of being introduced.