睾丸微小结石症不育患者精液中NO浓度及NAG活性的相关性分析

Analysis of correlation of testicular microlithiasis with content of nitric oxide and α-glycosidase in semen in patients with infertility

目的探讨睾丸微小结石症（TM）不育患者精液中NO浓度及α-糖苷酶（NAG）活性的相关性。方法应用高频超声共检出59例TM不育患者,同时检测患者精液中NO浓度及NAG活性。结果 59例患者中,经典型25例（42%）,局限型34例（58%）;43例发生于双侧,16例发生于单侧;伴精索静脉曲张（Ⅰ~Ⅲ度）43例,隐睾6例,睾丸鞘膜积液4例,睾丸囊肿6例。经典型、局限型患者双侧睾丸体积、双侧睾丸动脉阻力指数均无显著性差异,经典型患者精液中NO浓度、NAG活性及双侧睾丸动脉的峰值流速均明显不同于局限型,局限型与正常者相比无明显变化。结论 TM与精液中NO浓度及NAG活性存在着一定的相关性,但是73%TM患者伴精索静脉曲张,其机制有待于进一步研究。

Objective It is to study the correlation of testicular microlithiasis（TM） with the change content of nitric oxide and α-glycosidase（NAG） in semen in patients with infertility.Methods 59 patients with testicular microlithiasis were found by high-frequency ultrasound and the content of nitric oxide and α-glycosidase in semen in these patients were measured.Results 43 patients of testicular microlithiasis were found in two sides and 16 patients were found in one side,including 43 varicocele,6 cryptorchidism,4 testicular hydrocele and 6 testicular.Class testicular microlithiasis（CTM）in 25（42%）cases and limited testicular microlithiasis（LTM）in 34（58%）cases.NO,NAG in semen and bilateral testicular peak systolic velocity（PSV） had significantly differences in CTM（P0.05）.No significantly differences was found in LTM and normal.No significantly differences were observed in the age of onset,bilateral testicular volume,resistance index（RI）of bilateral testicular arteries.Conclusion The sonographic appearance of TM is conductive to the definite diagnosis of the disease.TM is correlated with NO and NAG in semen criterion,but 73% patients have VC,mechanism study is further need.