晚期日本血吸虫病的家庭聚集性研究

STUDY ON FAMILY AGGREGATION OF CASES OF ADVANCED SCHISTOSOMIASIS JAPONICA

目的：探讨晚期日本血吸虫病的家庭聚集性。方法：选择江西省玉山县８１ 例晚血和６７ 名非晚血的患者作为先证者和对照，调查其二级以内的亲属晚血患病情况，比较先证者近亲、远亲和对照组的患病率，并用 ０ 截尾 Ｐｏｉｓｓｏｎ 分布和０ 截尾负二项分布模型拟合晚血病例在人群中的分布，分析晚血的家庭聚集性。结果：先证者的一级亲属患病率高于二级亲属和对照组亲属；晚血在人群中的分布超越了 Ｐｏｉｓｓｏｎ 分布的概率范围而与负二项分布一致。结论：晚期日本血吸虫病具有家庭聚集性。

AIM:To explore the family aggregation of advanced schistosomiasis japonica.METHODS:Eighty one cases of advanced schistosomiasis(AS) and 67 cases of non advanced schistosomiasis with history of infections in Yushan County,Jiangxi Province were chosen as proband groups and control groups respectively,then grades 1 and 2 relatives of them were investigated on AS.Family aggregation of AS was analyzed through comparing the prevalence rate between the close and distant relatives of probands and controls and fitting the observed distribution of AS cases among the population by zero truncated Poisson distribution and zero truncated negative binomial distribution. RESULTS:The prevalence rate was higher in the close relatives (Group Ⅰ relatives) of the probands than in the distant relatives(Group Ⅱ relatives)of the probands and in the controls relatives.The observed distribution of AS was beyond the probability of the zero truncated Poisson distribution,but consistent with the zero truncated negative binomial distribution.CONCLUSION:Family aggregation of advanced schistosomiasis does exist.