鄱阳湖区血吸虫病防治试点研究(英文)

PILOT STUDY OF SCHISTOSOMIASIS CONTROL IN POYANG LAKE REGION

目的：纵向观察鄱阳湖区血吸虫病重疫区血吸虫病防治效果。方法：采取每年全民化疗结合健康教育的防治策略。此外，在 １９９６ 年血吸虫病易感季节，成年男性加服血吸虫病预防药物青蒿琥酯。结果：居民血吸虫感染率和感染度分别从 １９９２ 年的 ２６．０％ 和 １．９２ 下降到 １９９４ 年的 １０．７％ 和 ０．５５；居民肝、脾肿大，肝实质状况得到显著改善；１９９５ 年夏季试区遭受洪水灾害，居民血吸虫感染率和感染度又上升至１８．４％和 １．０４；１９９６ 年由于上述防治策略的继续实施及易感季节高危人群口服血吸虫病预防药物青蒿琥酯，居民血吸虫病感染率和感染度又下降至５．０％ 和０．２５。结论：每年全民化疗结合健康教育与高危人群口服血吸虫病预防药物是控制湖区血吸虫病的一项有效策略。

AIM:To perform a longitudinal survey of the control of schistosomiasis in Fanhu illage hyperendemic for schistosomiasis, Poyang Lake region of Jiangxi Province from 1992 to 1996. METHODS: Annual mass chemotherapy and health education were implemented in all investigated indiviuals, in 1996, artesunate was used in high risk population in transmission season as a prophylactic measure. RESULTS: The prevalence of S. japonicum infection reduced from 26.0% in 1992 to 10.7% in 1994, the intensity of infection (geometric mean of EPG of feces) in residents decreased from 1.92 in 1992 to 0.55 in 1994, and the morbidity indicators such as hepatomegaly and splenomegaly in the cases also have been improved significantly after chemotherapy. In 1995, both the infection rate and intensity of infection of schistosomiasis were recurred from 10.7% and 0.55 in 1994 to 18.4% and 1.04 respectively due to the floods. In 1996, the infection rate reduced to 5.0% and the intensity of infection also decreased to 0 25 due to the additional measure. CONCLUSION:A mass chemotherapy in conjunction with health education and oral artesunate for preventing reinfection in transmission season is effective for the control of schistosomiasis in lake regions.