复方蒿甲醚片治疗间日疟的效果

OBSERVATION ON EFFICACY OF ARTEMETHER COMPOUND AGAINST VIVAX MALARIA

目的： 观察复方蒿甲醚片治疗间日疟疗效的影响。方法：用复方蒿甲醚片（每片含苯芴醇 １２０ ｍ ｇ、蒿甲醚 ２０ ｍ ｇ）１６ 片３ ｄ 分服（ Ａ 组）、２０ 片５ ｄ 分服（ Ｂ组），氯喹伯氨喹８ 日疗法（ Ｃ对照组）三组分别治疗３６ 例、４１ 例和 ５５ 例。结果： Ａ、 Ｂ、 Ｃ三组的平均退热时间相近，分别为 ２２．３ ｈ、２３．２ ｈ 和２５．０ ｈ；平均原虫转阴时间为３３．５ ｈ、３０．５ ｈ 和４４．９ ｈ； Ａ、 Ｂ两组均显著快于 Ｃ组（ Ｐ＜ ０．０１）。治后９ 个月的临床复发率： Ａ、 Ｂ、 Ｃ组各为８４．９％ 、７８．８％和 ２２．９％ ； Ａ、 Ｂ组均显著高于 Ｃ组（ Ｐ均＜ ０／０１）。结论：两种治疗方案治疗间日疟均具有速效。

AIM: To observe the efficacy of artemether compound against vivax malaria. METHODS: Each artemether compound tablet contains 120 mg benflumetolum and 20 mg artemether.132 patients with vivax malaria were divided into 3 groups.Group A,36 patients received 8 tablets as an initial dose,followed by 4 tablets daily for 2 days;group B,41 patients received 8 tablets as an initial dose, followed by 3 tablets daily for 4 days;group C,55 patients receiving chloroguine primaquine served as control.Two patients of group A were voluntarily to be bitten by Anopheles dirus before and after medication to observe the influence of artemether compound on the sporogony. RESULTS: The average defervescence times for groups A,B and C were 22.3 h、23.2 h and 25.0 h( P >0.05),respectively,the average parasite clearance times were 33.5 h、30.5 h and 44.9 h,respectively,the average parasite clearance times of groups A and B were all significantly shorter than that of group C ( P <0.01).The replase rates of groups A,B and C were 84.9%、78.8% and 22.9%, respectively,followed up at nine months,the relapse rates of groups A and B were higer than that of group C( P <0.01). CONCLUSION: Two regimens of artemether compound have the advantage of high efficacy against vivax malaria.