急性淋巴细胞白血病患者可溶性白细胞介素-2受体与免疫表型

Serum Levers of Soluble Interleukin 2 Receptor in ALL Patients and Its Correlation with Immunophenotype and Prognosis

目的：探讨ＳＩＬ－ＩＲ水平与急性淋巴细胞白血病（ＡＬＬ）免疫表型关系及临床意义。方法：采用酶联免疫吸附法测定４６ 例ＡＬＬ患者血清ＳＩＬ－２Ｒ水平，用一组单克隆抗体和流式细胞仪检测其免疫表型。结果：发现ＡＬＬ患者血清ｓＩＬ－２Ｒ含量明显高于正常人，且淋、髓或Ｔ、Ｂ同时表达的ＡＬＬ高于Ｔ－ＡＬＬ和Ｂ－ＡＬＬ（ Ｐ＜ ０．０１），Ｔ－ＡＬＬ又高于Ｂ－ＡＬＬ（ Ｐ＜ ０．０１）。结论：ｓＩＬ－２Ｒ水平与ＡＬＬ免疫分型及预后有关，两者同时检测，可更好地预测ＡＬＬ化疗效果。

Objective:To measure the serum levers of sIL 2R and the immunophenotype in 46 newly diagnosed acute lymphoblastic leukemia (ALL) patients.Method:ELISA and a panel of monoclonal antibodies with FACS weve used.Result:That the serum levels of sIL 2R in ALL immunophenotypic subtypes were significantly higher than normal control values. Measurements in cases of hybrid acute leukemia (HAL) were higher than that in the T ALL and the B ALL(P< 0.01 ),and measurements in cases of the T ALL were higher than in the B ALL (P< 0.01 ).Conclusion: The levels of sIl 2R were related to immunophenotype and prognosis in ALL. Patients with the 2 makers mentioned above contributed to predict a treatment outcome.