苄基异喹啉化合物Mollinedine的抗实验性心律失常作用

The Antiarrhythmic Effects of Mollinedine

Mollinedine(Moll)5mg/kg,iv可显著提高恒速iv哇巴因诱发豚鼠心律失常的用量;显著降低大鼠iv CaCl2的死亡率;预防氯仿引起小鼠心室纤颤的发生;对抗大鼠心肌缺血复灌引起的心律失常;但对iv乌头碱诱发大鼠心律失常的作用无效。小鼠恒速iv Moll随剂量增加,心电图PR间期、QRS明显延长。Moll 5mg/kg iv能降低麻醉大鼠的收缩压、舒张压,左心室压、左室压的变化速率。降压与抑制心肌收缩力作用时间较短,很快可恢复到给药前水平。由此说明,Moll具有抗实验性心律失常作用。

Mollinedine (Moll) is a benzylisoquinoline compound.Its chemical structure is partly similar to tetrandrine and dauricine which have been reported to be antiarrhythmic and hypotensive agents.In the present study,the antiarrhythmic effects of Moll were studied in several experimental arrhythmic models.Pretreatment with Moll (5mg/kg iv) significantly antagonized arrhythmias induced by ouabain in guinea pigs.It markedly prevented ventricular fibrillation induced by chloroform in mice and reduced the mortality rate produced by iv CaCl2 in rats,but it has no efficacy in aconitine-induced arrhythmias.Moll is also effective in preventing reper-fusion-induced arrhythmias in anaesthetized rats.Moll (5 mg/kg,iv) can lower SAP,DAP,LVP,±dP/dtmax,but these parameters return to initial values prior to administration soon.