中国人群阿尔茨海默病载脂蛋白E基因多态性的Meta分析

Association of Apolipoprotein E Polymorphism and Alzheimer's Disease in Chinese Population:A Meta-analysis

目的综合评价中国人群载脂蛋白E基因多态性与阿尔茨海默病的相关性。方法计算机检索PubMed、EBSCO、中国学术期刊全文数据库、中国生物医学文献数据库和万方数据库,检索时间均为1990年1月至2010年12月,收集载脂蛋白E基因多态性与中国人群阿尔茨海默病相关性的文献。应用RevMan 5.0软件对各个纳入研究的结果进行一致性检验和数据合并,并评估发表偏倚。结果共纳入9个研究,合计1122例患者。Meta分析结果显示:等位基因apoEε4是中国人群阿尔茨海默病危险基因[OR=3.53,95%CI(2.49,5.00),P<0.05];等位基因ApoEε3是中国人群阿尔茨海默病保护基因[OR=0.52,95%CI(0.40,0.68)];基因型ApoEε4/ε4、ApoEε4/ε3、ApoEε4/ε2是中国人群阿尔茨海默病危险基因型[OR=10.17,95%CI(4.25,24.19);OR=2.57,95%CI(2.04,3.25);OR=1.94,95%CI(1.13,3.34)];基因型ApoEε3/ε3是中国人群阿尔茨海默病保护基因型[OR=0.67,95%CI(0.57,0.77)]。结论中国人群阿尔茨海默病与载脂蛋白E的某些等位基因和基因型具有相关性。

Objective To evaluate the relationship between genetic polymorphism of ApoE and Alzheimer＇s disease in Chinese population.Methods Such databases as PubMed,EBSCO,CNKI,CBM,and WangFang Data were searched from their establishment to December 2010 to collect the literature about the relationship between genetic polymorphism of ApoE and Alzheimer＇s disease in Chinese population.RevMan 5.0 was adopted to conduct consistency check and data merging,and to evaluate publication bias.Results ApoEε4 was the risky allele（P0.05） in Chinese population,and its pooled odds ratios and 95%CI was 3.53（2.49 to 5.00）.ApoEε3 was the protective alleles（P0.05） in Chinese population,and its pooled odds ratios and 95%CI was 0.52（0.40 to 0.68）.ApoEε4/ε4,ApoEε4/ε3,and ApoEε4/ε2 were the risky genotypes（all P0.05） in Chinese population,and their pooled odds ratios and 95%CI were 10.17（4.25 to 24.19）,2.57（2.04 to 3.25）,and 1.94（1.13 to 3.34）,respectively.ApoEε3/ε3 was the protective genotype（P0.05） in Chinese population,and its pooled odds ratios and 95%CI was 0.67（0.57 to 0.77）.Conclusion In Chinese population,some ApoE alleles and genotypes are associated with Alzheimer＇s disease.