Recklinghausen病的神经肉瘤及其移植瘤的超微结构观察

Ultrastructure of Neurosarccma in Morbus von Recklinghausen and Its Transplant Tumor

本文收集了7例Recklinghausen病,其中2例已恶变为神经肉瘤,并将该2例恶变瘤组织(原发瘤)移植到裸鼠的皮下,多代保株移植(移植瘤)。本文对原发瘤和移植瘤的超微结构作了详细观察。结果表明本瘤虽经多代移植,但移植瘤无论在细胞分化和形态结构上都是稳定的。

Morbus von Recklinghausen (MR),also called nturofibromatcsis,is a common disease of autosomal dominant inheritance.This paper presents seven cases of MR,two of which underwent malignant changes,developing into neurosarco-ma.The malignant tumors were transplanted into nude mice ard the transplantation was repeated in many generations.The primary and transplanted tumors were investigated by using electron microscopy.The results showed that the characteristics of the cellular differentiation and ultrastructure of primary tumors were retained through many transplant generations (case 1:34 generations,case 2:14 generations).If may be suggested that the cellular differentiation and ultrastructure of this tumor,though transplanted in many generations,are stable.The origin of this tumor is discussed.