二苯乙烯类化合物DPE_(10)和DPE_(12)对花生四烯酸促进豚鼠离体子宫肌条收缩活动的影响

Influence of Two Diphenylethylenes (DPE_(10) and DPE_(12))on Arachidonic Acid-induced Contraction of Guinea Pig Myometrial Strips in vitro

本文测定了我所合成的前列腺素合成酶抑制剂(PGSI)DPE_(10_)和DPE_(12)对豚鼠离体子宫肌条收缩的影响。结果表明,DPE_(10)和DPE_(12)与经典的PGSI消炎痛和萘普生一样,对花生四烯酸所致子宫收缩活动均有抑制作用,其中对子宫肌的收缩频率及张力的抑制尤为明显。4种化合物的作用强度大致相当。此外,还观察了DPE_(10)和DPE_(12)对15-甲基-PGF_(2α)对马来酸麦角新碱所致的豚鼠子宫肌条收缩的影响,证明两化合物不能对抗二药对肌条的兴奋作用。

DPE10 and DPE12,synthesized in our institute,were tested for their effects in suppressing the arachidonic-acid-induced contraction of guinea pig myomet-rial stripes in vitro.It was found that both compounds were as active as indome-thacin and Naproxen (two well-known PGSIs) in reducing the activity of contraction of myometrium after addition of arachidonic acid(AA).Their suppressing effects on the frequency of contractions and the muscle tone were remarkable.The effects of four compounds were approximately of the same level.Furthermore,the two compounds were tested for their influence on contraction of guinea pig myometrial strips stimulated by dl-15-methyl-PGF2α and ergometrine meleat.No antagonistic effects were observed with these two compounds.