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盐酸西替利嗪的合成工艺综述 被引量：8

Review on the Synthesis of Cetirizine Hydrochloride
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摘要 经过国内外大量文献的检索和分析,总结出盐酸西替利嗪的合成工艺,并对各种合成工艺路线的优劣作了初步的评价。 According to literature search,various synthetic processes of Cetirizine hydrochloride were summarized.A preliminary evaluation of the advantages and disadvantages of all synthetic processes was made.
作者 刘浩 徐勇 覃广德
机构地区 上虞新和成生物化工有限公司
出处 《浙江化工》 CAS 2011年第4期6-11,共6页 Zhejiang Chemical Industry
关键词 盐酸西替利嗪 合成 反应机理 Cetirizine hydrochloride synthesis reaction mechanism
分类号 TQ463.53 [化学工程—制药化工]
  • 相关文献

参考文献16

  • 1Guy D, Vincent Z, Guy B. Process for the preparation of 2-[2-[4-[(4-chlorophenyl)phenyl methyl]-1-piperazinyl] ethoxy]acetic acid and its salts: EP,801064[P]. 1996-04-10.
  • 2李荣东,朱志宏,段立新.盐酸西替利嗪的合成[J].中国药物化学杂志,2000,10(1):66-67. 被引量：15
  • 3Bahes E, Genese R-St, Lannoy J de, et al. 2-[4- (Diphenylmethyl)-l-piperazinyl]- acetic acids and theiramides: EP,58146[P]. 1985-06-25.
  • 4Lerman O, Gal E, Kaspi J. Process for the preparation of esters of [2-[4-[(4-chlophenyl) phenylmethyl]-l-piperazinyl] ethoxy]acetic acid : EP,952153[P]. 2000-08-08.
  • 5Hernandez P E, Fairfax D J, Michalson E T . Processfor preparing piperazine-substituted aliphatic carboxylates: WO, 0129016[P]. 2001-05-29.
  • 6Cossement E , Motte G , Bodson G, et al. Process for preparation of a 1-piperazine- ethoxyacetic acid: GB,2225321 [P]. 1990-05-30.
  • 7鞠波,胡晓红.盐酸西替利嗪的合成[J].中国医药工业杂志,1998,29(3):106-107. 被引量：4
  • 8Cossement E, Gobert J, Bodson G. Process for the preparation of a 1-piperazine-ethoxyacetic acid: GB,2225320 [P]. 1990-05-30.
  • 9何永志,刘东志.盐酸西替利嗪的合成工艺改进[J].天津医科大学学报,2003,9(4):488-490. 被引量：7
  • 10Jozsef R, Peter T, Ferenc B, et al. A process for the preparation of {2-[4-(α-phenyl-p- chlorobenzyl)piperazin-l-yl ]ethoxy}aeetic acid and novel intermediate therefore: WO, 0140211[P]. 2001-06-07.

二级参考文献16

  • 1[1]Baltes E, De Lannoy J, Rodriguez L. 2- [4- (diphenylmethyl) - 1- piperazinyl] acetic acids and their amides and pharmaceutical compositions[p] .Eur Pat Appl: EP58146, 1982 - 08 - 18
  • 2[2]Cossement E, Motte G, Bodson G, et al. Process for prepara tion of cetirizine, its dihydrochloride and optical isomers via hydrolysis and corresponding nitrles[p] .Brit UK Pat Appl: GB2225321, 1900 - 08- 30
  • 3[3]Cossement E, Gobert J, Bodson G Process for preparation of cetirizine and its dihydrochloride via etherification with haloacetates[p]. Brit UK Pat Appl: GB2225320, 1990 - 05 - 30
  • 4樊能廷.有机合成词典[M].北京:北京理工大学出版社,1992.328.
  • 5Yung D K，J Pharm Sci，1978年，67卷，7期，900页
  • 6Baltes E, De Lannoy J,Rodriguez L. 2-[4-(diphenylmethy)-1-piperazinyl] acetic acids and their amides and pharmaceutical compositions [P]. EP: 58146,1982-08-18.
  • 7Cossement E, Motte G, Bodson G, et al. Process for preparation of cetirizine, its dihydrochloride and optical isomers via hydrolysis and corresponding nitriles [P]. GB:2225321,1990-08-30.
  • 8Cossement E, Gobert J, Bodson G. Process for the preparation of cetirizine and its dihydrochloride via etherification with haloacetates [P]. GB:2225320,1990-05-30.
  • 9Hamlin K E, Buger W B. Histamine antagonists, unsymmetrical 1.4-disubstituted piperazines [J]. J A C A,1949,71:2 731.
  • 10Gilman H, Adams R. Marvel, Organic Synthesis, Collective Volume I, 2nd ed [M]. New York: John Wiley & Sons Inc, 1993.84.

共引文献24

同被引文献68

引证文献8

二级引证文献15

浙江化工
2011年 第4期

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