肝移植术后对肠道黏膜SIgA分泌的影响及意义

Effects of Liver Transplantation on Secretion of SIgA in Intestinal Mucosa

目的观察肝移植前后,肠道黏膜分泌型免疫球蛋白(secretory immunoglobulin A,SIgA)分泌变化情况,为临床施行肝移植术后胃肠道功能的恢复提供依据。方法选取20例肝脏病变行肝移植的患者和20例体格检查健康者作为研究对象,检测患者肝移植术前后和健康体检者粪便内的SIgA含量。结果肝移植患者肝移植术前SIgA较健康体检者低;肝移植术后,随着肝移植实施时间的变化,SIgA水平逐渐恢复正常,与健康体检者无差异。结论肝脏病变可导致胃肠道黏膜SIgA水平下降。随着肝移植手术的实施,肠道黏膜SIgA分泌接近正常,黏膜免疫功能得到明显的改善。

Objective To observe the changes of secretory immunoglobulin A（SIgA） in intestinal mucosa of patients before and after liver transplantation,and supply reference for the recovery of gastrointestinal immune function after liver transplantation.Methods SIgA in the dejecta of 20 healthy subjects and 20 patients before and after liver transplantation were detected and analysed.Results Before liver transplantation,SIgA contents in patients were lower than healthy subjects.After liver transplantation,SIgA contents increased gradually and arrived at the normal level.Conclusion Hepatocirrhosis can restrain the secretion of SIgA.After the liver transplantation,SIgA in the gastrointestinal mucosa can return to normal level gradually and the gastrointestinal immune function is obviously recovered.