纳米银抗菌水凝胶大鼠阴道给药后体内银元素的代谢与分布

Metabolism and distribution of elementary silver on nanometer silver antibacteria gel applied the rat vagina

目的研究纳米银抗菌水凝胶阴道给药后银元素在大鼠组织器官中的代谢与分布情况。方法雌性Wistar大鼠随机分为试验组与对照组,试验组每天阴道给纳米银抗菌水凝胶1次,剂量为1750μg,连续给药5 d;对照组不给药。采用原子吸收光谱法测定血清与器官中的银元素。结果试验组给药后血清银元素浓度逐渐上升,至第5天达到高峰,后呈下降趋势;银元素在大鼠体内的分布情况是:脾>肾>肾上腺>肝>肺>心>子宫和卵巢>脑。结论纳米银抗菌水凝胶阴道给药后在短时间内会产生一定浓度的蓄积。

Objective To study metabolism and distribution of elementary silver in several tissues of rats after nanometer silver antibacteria gel applied the rat vagina.Methods Pantheress Wistar rats were randomly divided into the test group and the control group.The 1750 μg of gel was administered to vagina once per day,continuously for 5 ds in test group.Don＇t give a medicine in control group.Adopt the atomic absorption spectrum method to measure the elementary silver content in serum and tissues.Results After the application of nanometer silver antibacteria gel,the serum elementary silver density in the test group increased gradually and attained peak 5th days,then showed a decreased trend.The distribution of elementary silver in the rat body was spleen〉kidney〉adrenal glands〉liver〉lung〉heart〉the womb and ovary〉brain.Conclusion The nanometer silver antibacteria gel has a good bio-safety applied in the vagina.