摘要
目的探讨急性有机磷中毒患者早期肾功能损害的监测方法。方法用放射免疫法对中毒组５５例，对照组３２例进行了血β２－微球蛋白及尿β２－微球蛋白测定，同时用美国ＢＥＣＫＭＡＮ全自动生化分析仪测定了血尿素氮和血清肌酐。统计学处理采用ｔ（或ｔ’）和χ２检验。结果发现尿β２－微球蛋白显著升高（Ｐ＜０．０１），而血β２－微球蛋白、尿素氮、肌酐变化不明显。结论提示急性有机磷中毒患者可伴有早期肾功能损害，血液生化指标对其不敏感，而尿β２－微球蛋白测定对监测急性有机磷中毒患者肾功能具有一定临床治疗意义。
To research the methods to detect the
early renal damage in patients with acute organophosphorus poisoning(AOPP). Methods The
contents of the serum 2-mictroglobulin(2-MG) and urinary 2-MG were determined in 55
patients with AOPP(poisoned group) by radioimmunoassay and compared with those of 32
mormal persons(control group). Blood urea nitrogen(BUN) and serum creatinine(scr) were
determined by biochemical analyzer.The t-test(or t'-test) and 2-test were took in statistical
treatment. Results The levels of urinary 2-MG of the poisoned group was remarkably higher
than that of the control group(P<0.01),but the changes of serum 2-MG,BUN,Scr were
insignificant. Conclusion AOPP may complicate the earlier renal damage.The detection of
urinary 2-MG might be helpful to the discorery of early and mild renal damage in patients with
AOPP and it is valuable for treatment.
出处
《新乡医学院学报》
CAS
1999年第2期96-97,100,共3页
Journal of Xinxiang Medical University
基金
国家"九五"攻关课题
