摘要
目的本文旨在探讨左旋咪唑预防食管癌的作用及与免疫的关系。方法Wistar大鼠90只,随机分为三组,分别给左旋咪唑、太洛龙(阳性对照)、生理盐水(阴性对照),用甲基戊基亚硝胺MANA诱发食管癌前病变,经105天实验后,检测食管癌前病变发生率,并测定免疫器官指数,外周血T淋巴细胞和自然杀伤细胞(NK细胞)。结果显示左旋咪唑降低食管癌前病变发生率的作用和太洛龙(Til)相似,并使外周血T淋巴细胞和NK细胞明显增加。Til组NK细胞无增加。结论左旋咪唑和太洛龙具有相似地预防亚硝胺诱发食管癌作用,并与增强机体免疫功能相关。
Objective The purpose of the parper was to study the preventive effects of levamisole on
esophageal carcinogenesis. Methods The test was carried out in 90 Wistar rats,randomly
divided into 3 groupsOne group fed with levamisole,with positive control of tilorone and
negative control of physiological saline solution.Their precancerous lesions of the esophagus
were induced by N-methyl-N-amylnitrosamine 5mgKg-1sc.After 105 days of experiment,the
incidence of precancerons lesions of the esophagus,the index of immune organs and the
percentage of T lymphocyte and NK cell in the peripheral blood were determined. Results
Similar to tilorone the levamisole a significantly decreased the incidence precancerous lesions
of the esophagus and increases of the percentage of T lymphocyte and N cell in blood of rats
similar to tilorone. Conclusion The levamisole and tilorone have similar preventive fuction to
esophageal carcinogenesis induced by nitrosamines.Which could be attributed to increasing
the immunity.
出处
《新乡医学院学报》
CAS
1999年第2期122-123,126,共3页
Journal of Xinxiang Medical University
关键词
左旋咪唑
太洛龙
食管癌
癌前病变
致癌作用
levamisole
tilorone
nitrosamines
precancerous lesions
esophagus
carcinogenesis