急性心肌梗塞患者血清蛋白I变化的临床意义

Significance of changes of serum cardiac troponin in patients with acute myocardial infarction

目的探讨急性心肌梗塞（ＡＭＩ）患者血清肌钙蛋白Ｉ（ＣＴｎⅠ）含量变化的临床意义。方法对３２例急性心肌梗塞患者和３６例健康对照者血清中肌特异性肌钙蛋白Ｉ和磷酸肌酸激酶（ＣＫ－ＭＢ同功酶）活性进行检测，并分析其与ＡＭＩ临床特征的关系。结果所有３６例健康对照者血清ＣＴｎⅠ均为阴性；３２例急性心肌梗塞患者中２８例ＣＴｎⅠ阳性，２５例ＣＫ－ＭＢ阳性。结论ＣＴｎⅠ是一个特异、敏感的反映心肌损伤的血清标记物。

Objective To research the clinical significance of the changes of serum cardiac troponin (CTnI) in acute myocardial infarction Methods The contents of serum CTn and creaine kinase isoenzyme MB (CK-MB) activity were measured by enzymoimmunoassay method in 32 patients with acute myocardial infarction (AMI) and 36 control healthy subjects, and assay the relation with those clinical characters of AMI Results All 36 control healthy subjects were negative for CTnI; 28 of 32 patients with AMI were positive for CTnI and 25 of those patients were positive for CK-MB The contents of serum cardiac specific troponin were related with the ranges of myocardial infarction and heart function Conclusion CTnI was a specific and sensitive serum indicator of myocardial cell injury