肝病患者肝组织内前S蛋白表达、炎性细胞浸润与肝细胞坏死的研究

The Relationship of pre-S Proteins Expression in Liver Tissues,Infiltration of Inflammatory Cells to Liver Cell Necrosis of Patients with Liver Diseases

研究观察了30份肝病患者肝组织标本前S蛋白表达、炎性细胞浸润与肝细胞坏死的关系,结果表明:NK细胞和B细胞并非前S阳性肝细胞区域主要的炎性细胞成分,前S膜表达并伴有肝细胞坏死的区域主要是OKT^+_3的T细胞浸润,这些细胞可同时表达Ia抗原,为活化的T细胞,推测前S可能与HBsAg共同诱导宿主以T细胞为主的免疫应答,导致肝细胞坏死。

30 samples of liver with acute or chronic liver disease were used to study the relationship of pre-S expression,infiltration of inflammatory cells to liver cell necrosis.Our results suggested that NK cell and B cell are not the main infiltrating cells in the areas positive for pre-S,but OKT3+T cells are the main ones of the infiltration in the areas positive for membranous expression of pre-S complicated by liver cell necrosis and these T cells may at the same time express Ia antigen,indicating that they may belong to activated T cells.Thus,we may be led to conclude that together with the HBsAg,pre-S may induce the host's immune response mediated mainly by T cells,thereby causing liver cell necrosis.