山莨菪碱对胎盘胎儿血液循环影响的实验研究

An Experimental Study of Anisodamine Effect on Placental-Fetal Circulation

本文采用放射微球等技术研究山莨菪碱(654-2)对胎盘胎儿血液循环的影响。结果表明山莨菪碱[1.25mg/(kg·min)]能使正常晚孕兔母体胎盘血流量增加66％,同时增加肝脏、脾脏血流量。山莨菪碱(5.8×10^(-3)mol/L)对正常足月妊娠妇女胎盘绒毛组织TXA_2及PGI_2体外生物合成无明显影响。山莨菪碱 (5.4×10^(-4)及8.8×10^(-4)mol/L)能抑制5-HT或KCl引起的人脐动脉条肌张力。结果提示山莨菪碱有改善胎盘儿血液循环的作用,其作用并非通过抑制前列腺素生物合成而实现。

The effect of anisodamine (654-2) on placental-fetal circulation was studied in this paper,using radioactive microspheres and other techniques.Anisodamine [1.25 mg/(kg·min)] increased the blood flow in placenta of healthy late-pregnant rabbits to 166%,and the blood flow in liver and spleen as well.This drug (5.8×10-3 mol/L) exerted no signififant influence on in vitro biosynthesis of TXA2 and PGI2 in placental and villous tissues of parturient women,and it (5.4×10-4 and 8.8×10-4 mol/L) could inhibit the increased tonus,caused by 5-HT or KCl of umbilical arteries.The above results suggest that anisodamine can improve the placental-fetal circulation.This effect seems not to be mediated through influencing biosynthesis of prostaglandins.