侧脑室内注射微量γ-氨基丁酸对大鼠胃和十二指肠运动的影响

Effect of Intracerebroventricular Microinjection of GABA on Gastric and Duodenal Motility in the Rats

本文以定点记录大鼠胃和十二指肠运动的方法,观察侧脑室内注射(i.c.v.)微量γ-氨基丁酸(GABA)对胃和十二指肠运动的影响,发现GABA能显著增强胃和十二指肠运动。一叶萩碱(i.c.v.)、阿托品(i.H.)或切断膈下迷走神经,均可完全阻断这一增强效应 而该效应却不受酚妥拉明(i.c.v.或i.m.)、心得安(i.c.v.或i.m.)或阿托品(i.c.v.)的影响,提示GABA在脑内可能刺激中枢内与调节胃肠运动有关的神经核团,经迷走神经使胃肠运动增强。

With the fix points method for recording gastric and duodenal mo-tility the effect of intracerebroventricular (i.c.v.) microinjection of GABA on gastric and duodenal motility in the rats had been studied.It was found that i.c.v.injection of GABA significantly strengthened the gastric and duodenal motility.These effects were abolished by injection of securinine alkaloids(i.c.v.),atropine (i.H.) or by vagotomy.However,the gastric and duodenal motility remained unaffected by administration of atropine(i.c.v.),regitine and propranolol (i.c.v.or i.m.).These findings indicate that in the brain GABA seems to stimulate the neur onal system controlling the vagus efferents involved in the regulation of the gastric and intestinal nervous system,which in turn causes some increase of gastric and intestinal motility.