我国不同地区各型肝病肝组织中HDV感染状态的研究

Studies on Hepatitis D Virus Infection in Liver Tissue of Hepatitis B Patients in China

应用直接酶标法对来自全国17个地区的2346份肝组织标本进行了肝内HDAg的检测,1764份HBsAg阳性标本中有167份检出HDAg,检出率为9.47％。各大地区HDAg检出率无显著性差异。肝内HDAg的检出率与病理类型有关,慢性肝病和重症肝炎中HDAg检出率较高。提示:HDV感染与疾病的活动性及慢性化有关。对HDV与HBV复制关系的研究表明:HDV可以抑制HBV的复制,但两者也可同时复制,其机理尚不清楚。

Intrahepatic hepatitis D antigen (HDAg) was detected in 2 346 liver samples from 17 districts in China by direct enzyme-labeled technique.HDAg was detected in 167 out of 1 764 samples of HBsAg positive individuals with the detective rate of 9.47%.There existed HDV infection in all detected areas without any significant difference in terms of HDAg detective rate.It was found that intrahe-patic HDAg was related to the pathologic type of liver disease.The HDAg detective rate was higher in chronic liver disease and severe hepatitis than in other liver diseases.It is suggested that HDV infection was associated with the progression and chronicity of the liver disease.Studies on the relationship between HDV infection and HBV repication showed that HBV replication might be suppressed by HDV infection.Both HDV and HBV,however,could be replicated simultaneously in the same hepatocyte.