摘要
6名早孕妇女用米非司酮合并前列腺素终止妊娠过程中,测定了血皮质醇、皮质酮、醛固酮和ACTH的变化,与6名健康者进行了对比。结果:皮质醇、皮质酮和ACTH服药后2~4h上升,24h时达峰值,以后逐渐回复至给药前水平。提示:米非司酮终止妊娠过程中,垂体-肾上腺功能发生急性代偿性变化。推论与米非司酮拮抗了糖皮质激素对丘脑下部-腺垂体的负反馈机制有关。
6 pregnant women (below 49 days of amenorrhea) received 600mg mifepristone orally in a single dosage and 1 mg PG-05 or ONO-802 as vaginal suppository 48 hrs afterward.Plasma cortisol,corticosterone,aldosterone and ACTH were monitored at-1/2,1,2,4,10,24,48,72 hrs and a follow-up visit was made on 8th day Cortisol increased during the treatment and the values returned to the pretreatment level on the first follow-up visit.The changes of corticosterone were similar to those of cortisol.ACTH was also elevated within first 2 hrs and returned to the basal level at 48 hrs.There was no significant change in aldosterone during the treatment.The above results,suggest that a compensation of the pituitary-adrenal function occurred during the treatment,which is probably associated with decreased negative feedback mechanism of cortisol at the hypothalamus level due to the antiglucocorticoid activity of mifepristone.
出处
《同济医科大学学报》
CAS
CSCD
北大核心
1990年第4期251-253,共3页
Acta Universitatis Medicinae Tongji
关键词
米非司酮
糖皮质激素
垂体
肾上腺
mifepristone
pituitary-adrenal system
glucocorticoids
termination of early pregnancy