热毒清与抗生素联用治疗小儿肺炎的临床疗效和T细胞亚群的观察

Observations on Clinical Effects and T Cell Subsets in Children with Pneumonia Treated by Combined Therapy of Re Du Qing and Antibiotics

中药热毒清结合抗生素(简称中西药组)和单用抗生素(称抗生素组)分别治疗小儿肺炎各30例。结果表明:中西药组的主要症状、体征如气喘、咳嗽,紫绀、肺部哮鸣音和中小湿罗音等消失,均较抗生素组为早(P<0.05);前组痊愈率为100.0％,明显高于后组的83.33％(P<0.05)。治疗前,两组患儿的OKT^+_4细胞皆较正常值为低,OKT^+_8细胞皆较正常为高(P<0.01)。经治疗后,两组OKT^+_4细胞都可恢复正常,而OKT^+_8细胞仅在中西药组恢复正常。

60 children with pneumonia were treated either by the therapy of Re Du Qing,a Chinese traditional medicine,with antibiotics or by the therapy of antibiotics alone.Experimental results show that in the group treated by the formal therapy,the main symptoms and signs,such as wheezing,cough,cyanosis and some pulmonary abnormal auscultation etc.,disappeared earlier than those in the group treated by the latter therapy (P<0.05).The cure rate is 100.0% in the group by combined therapy and 83.33% in the group by antibiotic therapy alone (P<0.05).Before the treatment,in all patients the OKT4+ cells were less and OKT8+ cells were more than those in normal children (P<0.01).After treatment,however,the OKT4+ cells increased to normal range in both groups (P<0.05),but the OKT8+ cells decreased to normal only in the group of combined therapy (P<0.05).From the above,it may be suggested that the therapeutic effect is enhanced by the addition of Re Du Qing.